I was diagnosed with acid reflux about 5 years ago and am currently taking 40mg Protonix once daily. Everything seemed to be okay for a while, but recently I have been having severe anxiety that has been causing chest pain. I have been to the doc and to the er for the standard test, blood work up, ekg, chest ct, and chest e-ray. The doctor says my heart is fine, but the pain is still there. About three days ago I started having the bad heartburn, I think, again and am going to be getting my peroid any day. Is it possible that the anxiety or the hormones are making my reflux worse.