I have been taking Prilosec for 9 months. I have no Yeast problem, but I did have a B12 deficiency: A problem that can occur with taking PPI's for a long time. I take a B12 lozenge under the tongue to compensate. Stomach cannot process B12 due to PPI reducing the stomach acid.
If you are taking PPI's for a long time, please look up the symptoms of a B12 deficiency... some are weakness/tired a lot, pale skin, sore red tongue, weight loss, nauseau, diarrehea/constipration, Shortness of breath, tingling in hands/feet, paplitations, yellowish tinge to skin. I am sure there are more so google it.
B12 is a specific blood test your doctor can request.
Also Prilosec after awhile gives me gas (farting in early Am then small burbs all day). Just an annoyance.