So, all this started after Reglan? Was she taking any other drugs at that time (for anxiety maybe...?)
Liver disease mentioned, was it Reye's syndrome?
I've found connection between Reglan and Neuroleptic malignant syndrome
Just look at these search results:
Read this article (or serach for others):
Thank you for the ideas. She was taking Ativan that they gave her because they thought there were anxiety attacks.
We don't know if there is a liver disease, but the doctor's indicated that some sort of liver disease may be present to cause these numbers/results.
Ativan is actually used in treatment of neuroleptic malignant syndrome, so it should not be problematic, but Reglan is.
Reye syndrome is not likely, I've checked again.
Read these article, it shows causes, risk factors, culprit drugs, laboratory findings, including elevated liver enzymes:
(it's another version of above mentioned article)
The doctor just came in and is thinking autoimmune hepatitis. Labs came back that it doesn't appear to be viral, but could be from medicine. What a long route. We are hoping this is the answer, but have not really had good luck with diagnoses in the past six months.
Now, if it is, we will have to monitor the steroids carefully as there appear to be quite a few side effects.
Why not start from what is obvious?
She was taken off the Reglan after the side effect a couple weeks ago. We know that was part of the problem, but not the original problem. She was on Reglan for four days! What a deal.
For days of Reglan is enough for NMS...
QUOTE from emedicine.com/Med/topic2614.htm
"The syndrome can occur after any duration of treatment, although two thirds of cases occur within the first week."
But NMS should go away shortly after the drug removal. There are other side effects of Reglan, which may be the cause.
Liver enzymes may need quite some time to drop to the normal level.
Autoimmune hepatitis or eventual other liver damage can be only checked by liver biopsy and hystologic examination.
But, as I understand you, abdominal pain and weight loss occured before Reglan, right?
Weight loss is either from
- loss of appetite
- malabsorption - STOOL FAT TEST would show excessive fat
- cancer: there are many characteristic substances in the blood, which speak for cancer. They are called "cancer markers". Specific tests should be done to find them, probably by oncologist.
jHi boron,just a quick one, is motilium and reglan the same
The substance in Motilium is domperidone, and in Reglan is metoclopramide. They are both anti-emetics.
You can find brand name of almost any drug in deugs.com under "advanced" link. Wikipedia article about domperidone seems interested.
Thanks boron, i will check out the site.I was placed on motilium like 3months ago.Although i have stopped using it now(Doc says so).However for the 3 months that i was on it, my period ceased.I have stopped now and i am hoping i resume my normal monthly circle