I have had moderate to severe upper abdominal pain for the last 2-3 years. I tried aciphex, which worked great for about 6 months, then stopped working. I switched to taking tums multiple times a day, which worked for a couple months and then stopped. I tried Kapidex which also worked perfectly for about 3 months and then completely stopped working. Zantac worked for about a month and is now subsiding. My doctor has added carafate, but the pains are still not gone. They usually come when I haven't eaten for a while and let myself get hungry at all. I try to eat every 2-3 hours but am not always able to. I had an endoscopy recently which showed some gastritis and irritation, but nothing else. I tested negative for H. Pylori. My GI doc thinks I just produce too much acid, but he doesn't know why the antacids and PPIs only work for a short time and then stop working. At this point, all he can say is that I'll probably "outgrow" it. I'm almost 30, and this is effecting my quality of life, always having to worry about when I can eat and when the pains are going to begin next. Any suggestions?