Hi, are you referring to colitis? therapy will depend on the type of colitis you have. Ulcerative colitis may require lifelong medication therapy if surgery is not done. Other types, such as ischemic colitis, usually improve without surgery. Pseudomembranous colitis generally responds well to antibiotics but may recur. When there is inflammation of the bowel it causes stretching of the peritoneum and consequent pain. Once the inflammation subsides the pain will resolve. Regards.