Sorry, this is gross, but since it happened to me twice, I wondered if any one else experience this. First time was about 10 years ago: I had a wonderful meal at a restaurant with red wine and before going to bed took an antacid. I felt my intestines churning and woke up with signs of diarrhea on my underwear. Last evening, again after a great meal and red wine, I took a Tums. In the morning, same thing -- diarrhea signs on my underwear!! Does anybody know if antacids interact with red wine to cause diarrhea?