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the kidney

My brother has an elevated blood uric acid and elevated SGPT does he has a kidney problem?
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363281 tn?1518219421
Well, a high uric acid "might" mean some kidney malfunction, but you would need other tests to make sure.

The blood uric acid test measures the amount of uric acid in a blood sample. Uric acid is produced from the natural breakdown of your body's cells and from the foods you eat.

Most of the uric acid is filtered out by the kidneys and passes out of the body in urine. A small amount passes out of the body in stool. But if too much uric acid is being produced or if the kidneys are not able to remove it from the blood normally, the level of uric acid in the blood increases.

High levels of uric acid in the blood can cause solid crystals to form within joints. This causes a painful condition called gout. If gout remains untreated, these uric acid crystals can build up in the joints and nearby tissues, forming hard lumpy deposits called tophi. High levels of uric acid may also cause kidney stones or kidney failure.

SGPT is a test for liver function.

SGOT/SGPT blood test is a one of the liver function tests. Primary use of SGOT/SGPT blood test is to assess the state of the liver function. SGOT and SGPT are two enzymes found in the liver.

SGOT; serum glutamic oxaloacetic transaminase: Aspartate transaminase (AST)
SGPT; serum glutamic pyruvic transaminase: Alanine transaminase (ALT)

SGOT is found in the cytosol of the liver cell whereas SGPT is found in the mitochondria. This is why mild and moderate liver damage gives high SGOT and normal SGPT (usually) value and sever liver damage gives high SGOT /SGPT blood test value. Other tissues where SGOT enzyme found are red blood cells, cardiac muscle, skeletal muscle, kidney and brain tissue therefore damage to these tissues result in high SGOT level in the blood. SGPT is also found in cardiac and skeletal muscles therefore damage to these tissues can result in elevated SGOT/SGPT blood test value. If SGOT/SGPT blood test is ordered by your doctor, you may be suffering from some kind of liver disease such as hepatitis (viral or alcoholic). Normal and high SGOT/SGPT test values and their possible causes are given below.

Normal SGOT/SGPT test value;

1. SGOT; Normal Adult Range: 0 - 48 U/L
2. SGPT; Normal Adult Range: 0 - 42 U/L

High SGOT/SGPT test values found in following conditions;

1. viral hepatitis
2. alcoholic liver diseases
3. non alcoholic liver disease
4. liver cell necrosis

I guess what I am trying to say is ask your doctor, both tests can show much more than faulty kidneys, there are others to help rule it out.
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363281 tn?1518219421
Nelson, New Zealand
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way off the beaten track!, BC
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