Although I am not familiar with the Navy policy on Factor V Leiden, I may be able to give you some points for discussion. We recommend that your daughter meet with a medical geneticist for evaluation and to understand the risks associated with Factor V Leiden. A medical geneticist can be found at the American College of Medical Genetics website. Letters from a medical geneticist and hematologist may also be useful in your case.
- About 3% to 8% of Caucasians in the United States and Europe have one copy of the Factor V Leiden mutation (heterozygous). Most people with the Factor V Leiden mutation never develop abnormal blood clots.
- Other factors also increase the risk of blood clots in people with the Factor V Leiden mutation. These factors include increasing age, obesity, trauma, surgery, smoking, the use of oral contraceptives (birth control pills) or hormone replacement therapy, and pregnancy. The combination of the Factor V Leiden mutation and mutations in other genes involved in blood clotting can also influence risk.
- In the general population, the risk of developing an abnormal blood clot is about 1 in 1,000 people per year. People with one copy of the Factor V Leiden mutation have an increased risk, about 4 to 8 in 1,000. As you know, people with two mutations have an even higher risk - as high as 80 in 1,000.
We hope you find this information helpful and wish you and your daughter the best.