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? on MTHFR mutation inheritance

Our family has undergone testing for MTHFR mutations, due to multiple children with developmental delays.I am positive MTHFR heterozygous for C677T/negative for A1298C; husband came back negative for both. 2 girls are positive heterzygous A1298C & negative for C677T? We are waiting for other 2 kids results yet. HOW IS IT POSSIBLE OUR GIRLS HAVE A MUTATION FORM NEITHER OF US TEST POSITIVE FOR?
2 Responses
Avatar universal
That sounds rather strange. I would definitely be asked to be retested and go through another lab for the work. At diagnosis, I was only told I was 677 and don't worry, this one pill will be fine. I was getting sicker and sicker. Come to find out the foltx is a synthetic B supplement that was building up more toxins in my body b/c it is a cyanide derivative. The entire time, I needed the methyl (natural) form of B. Now I am A1298C and C677T. If you would like to email me, you may. ***@**** I have tons of research, articles and journals that I can email you that have been given to me by other people with MTHFR mutations.
Avatar universal
I would suggest meeting with a perintolgist & they can explain how it comes through the gene pool.  Another option is to ask whomever ordered these tests.  Best Wishes
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