Thank you for your post and welcome to our forum.
HLA-DR4 is a cell surface receptor encoded by the human leukocyte antigen (HLA) complex on chromosome 6. HLA were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in mismatched donors. HLA-DR4 is also involved in some autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, phemphigus, obstructive hypertrophic cardiomyopathy, IgA nephropathy, and polymyalgia rheumatica. It is associated to different ethnic groups, including Askenazi Jews.
Cases of false positive results of HIV tests have been associated to the presence of HLA-DR4, not false negative. The fact that all your tests were negative, there is no reason for you to be concerned as your results are conclusive, regardless of the fact that you might carry the HLA-DR4 receptor.
It has nothing to do with the ability of you being able to produce HIV antibodies, but it has to do with a cross-reaction specifially seen in HIV Duo tests where a false positive reaction can sometimes occur. No false negative test results have been reported in this cases. I can assure you that your negative test results are fully conclusive.
Copyright 1994-2018MedHelp.All rights reserved. MedHelp is a division of Vitals Consumer Services, LLC.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.