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Avatar universal

Immunomodulatory Drugs: Can they affect HIV Test

Dear Doctors --

Let me give you the context of my situation and then my question itself.

2 months ago, For close to a month I had been participating in a drug trial, taking the drug Laquinimod -- an "Immunomodulatory" Drug. [Wikipedia Link here: http://en.wikipedia.org/wiki/Laquinimod ]

Please note that my intake was somewhere around 0.6mg per day but maybe double that, im not sure.

About two weeks into my drug intake I had a lower-risk sexual encounter. My drug intake continued for another week after this encounter.

Because of my concern about my sexual encounter, 5 weeks after the sexual encounter and **my major concern** -- a month after I ended taking Laquinimod **-- I got an Orasure Rapid HIV test as well as an STD Screen (which actually included a HIV blood test).

My question to you: Would this drug affect the result of an HIV test 1 month after the last intake of the drug? If so -- how long will I need to wait before being able to take a test without any intereference from the drug? I am considering testing again this coming week -- which puts me 2.5 months out from my sexul encounter and 2 months after I stopped taking the drug -- but would gladly save the money if you don't think its necessary.

Thank you for your time and expertise. Both are very appreciated.
8 Responses
239123 tn?1267651214
Reacting only to the title you selected for this thread, before I read the question itself:  There are few if any medical therapies that affect the reliability of HIV testing.  The only drugs that might do so are very potent immunosuppressive drugs in high doses, or potent chemotherapy of the sort used for widespread cancer.  Even those are theoretical only, with few if any actually documented cases of interference with HIV diagnosis.

Now I have read the question itself.  Laquinimod is a new, experimental drug that might have promise for multiple sclerosis and perhaps other immunological disorders of the nervous system.  I very much doubt it would interfere with standard HIV antibody testing, including the oral fluids test, since almost nothing does.  However, to my knowledge there is no research on this.  In situations involving new, experimental therapies, the investigators doing the research are by far the most knowledgeable about the drug. You need to ask the researchers responsible for your research study.  I will be surprised if they are concerned about interference with your OraQuick test, but please let me know if they say otherwise.

You don't describe the nature of your possible exposure to HIV.  But barring a surprise from your research team, you can be sure you didn't catch it.  Whether or not you should have still further testing depends on the risk:  the lower the chance of catching HIV, the less important it is to test out to 6 weeks or 3 months.  Use the search link to find innumerable other threads on the topic of seroconversion window, i.e. time to positive HIV tests.

Best wishes--  HHH, MD
Avatar universal

Doctors -- Please forgive the additional post below but I want you to have all the information I do. Turns out I was also being taking Moxifloxacin as well -- somewhere around the same amount for the same duration. Please consider this when giving me advice. I appreciate it.
239123 tn?1267651214
No antibiotics, moxifloxacin or any other, have any effect on HIV test reults.
Avatar universal
Thanks doctor --

Would it be easier for me to get another test -- this one would be 2.5 months after the last intake of Laquinimod -- Or do you think the drug may still have an affect on an HIV test -- and as a result I need to contact the research team to be sure?
239123 tn?1267651214
I can't answer this, not knowing anything about your potentially risky exposure, and not knowing for sure about the drug you are on.  Stop trying to figure this out on your own or by distant online advice from me or anyone else.  Pick up the phone and ask the research team.

I won't have any further comments.
Avatar universal
Dr --

Called the research team and the physicians there agree with you -- they think it highly unlikely that Laquinimod would have an affect on an HIV test.

The physician in charge of the study is on vacation until monday. The research group told me they will have him give me a call. I will post a recollection of his comments.

Thanks for all you time
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