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About detecting of last stage of age
Dear doctor, Can HIV antibody be detected in last stage of AIDS patient by elisa test.One of my relative had several exposure in 9 years ago with prostitude when he was in a UN mission in africa. Some web site for example google books says antibody can not be detected at advanced stage of infection. Is it right.........He is suffering from some infection for months........His elisa test is negative.........please answer..... Your faithful Salauddin
If seroreversion can happen with 2nd gen then it will happen with 3rd and 4th gen.
The difference between a 3rd gen and 2nd generation test is that a 3rd gen looks for IgM. IgM disappears shortly after IgG, which is what 2nd generation uses to detect HIV. I can't recall the number of weeks.
The difference between a 3rd gen and a 4th gen is that it in addition to antibodies looks for p24 antigens. These antigens disappear around week 5 - 6.
So in a person who is full blown AIDS, they would be well past these two stages of IgM and p24. Thus any test would be no different then taking a 2nd gen (or for that matter 1st gen) test, when seroreversion has been reported.
So much for theory.
In this situation, I'm with HowardH, a person would have to pretty sick for a pretty long time.
Hope your uncle feels better soon.
Be well
The difference between a 3rd gen and 2nd generation test is that a 3rd gen looks for IgM. IgM disappears shortly after IgG, which is what 2nd generation uses to detect HIV. I can't recall the number of weeks.
The difference between a 3rd gen and a 4th gen is that it in addition to antibodies looks for p24 antigens. These antigens disappear around week 5 - 6.
So in a person who is full blown AIDS, they would be well past these two stages of IgM and p24. Thus any test would be no different then taking a 2nd gen (or for that matter 1st gen) test, when seroreversion has been reported.
So much for theory.
In this situation, I'm with HowardH, a person would have to pretty sick for a pretty long time.
Hope your uncle feels better soon.
Be well
No comment. The question is too obvious to need a reply. Anyway, this is a thread jump; you can ask questions in your own thread.
Patients with late stage HIV (i.e. overt AIDS) are obviously sick, have had life-threatening illnesses due to immune system failure, usually lots of weight loss and many other symptoms, and are at risk for dying at any time. Pretty similar to terminal cancer. Anybody who is outwardly well almost certainly doesn't have it.
I don't think seroreversion has been reported for the newer HIV antibody tests (3rd generation), and for sure this isn't going to happen with the duo test.
It's the possibility of "seroreversion" that cause CDC to redefine AIDs by CD4 count and not antibody tests.
What's more in the early days of HIV/AIDs, there were some people who would point to these rare cases and insist that HIV does not cause AIDs.
Be well
What's more in the early days of HIV/AIDs, there were some people who would point to these rare cases and insist that HIV does not cause AIDs.
Be well
It's called "seroreversion" and it can happen.
People in end stage AIDs can stop producing antibodies. But it's very rare.
But I think if you uncle had it only for 9 years, he would still have antibodies.
Be well
People in end stage AIDs can stop producing antibodies. But it's very rare.
But I think if you uncle had it only for 9 years, he would still have antibodies.
Be well
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