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HIV Seroconversion Question
There was a survey in US conducted in 1993 by CDC with following report.
The survey of 230,179 cases of AIDS reported to the AIDS Reporting System initially revealed 299 HIV-seronegative patients. The evaluation of 172 of these patients (58 percent) is complete. Of these 172 patients, 131 have been reclassified as being HIV-positive, 4 have been reclassified as having some other type of defined immunodeficiency, and 8 HIV-exposed infants died before their serostatus could be determined. Twenty-six seronegative patients with AIDS had died, and 1 could not be located, but the race, age, reported risk factors for HIV infection, and history of AIDS-defining conditions of these 27 patients were comparable to those of HIV-seropositive patients with AIDS. Their mean age was 38 years; 89 percent were male, 74 percent were white, and 78 percent had risk factors for HIV infection (63 percent had engaged in homosexual sex, 11 percent were injection-drug users, and 4 percent had received transfusions). According to available information, none had had HIV cultures or experimental tests for HIV, such as PCR for retroviral DNA sequences.
Can anybody answer why the 299 cases initially seronegative with AIDS?. Is this becuase low sensitive assays used those time?. Or AIDS diagnosied in some other way?
The survey of 230,179 cases of AIDS reported to the AIDS Reporting System initially revealed 299 HIV-seronegative patients. The evaluation of 172 of these patients (58 percent) is complete. Of these 172 patients, 131 have been reclassified as being HIV-positive, 4 have been reclassified as having some other type of defined immunodeficiency, and 8 HIV-exposed infants died before their serostatus could be determined. Twenty-six seronegative patients with AIDS had died, and 1 could not be located, but the race, age, reported risk factors for HIV infection, and history of AIDS-defining conditions of these 27 patients were comparable to those of HIV-seropositive patients with AIDS. Their mean age was 38 years; 89 percent were male, 74 percent were white, and 78 percent had risk factors for HIV infection (63 percent had engaged in homosexual sex, 11 percent were injection-drug users, and 4 percent had received transfusions). According to available information, none had had HIV cultures or experimental tests for HIV, such as PCR for retroviral DNA sequences.
Can anybody answer why the 299 cases initially seronegative with AIDS?. Is this becuase low sensitive assays used those time?. Or AIDS diagnosied in some other way?
Seronegative means they are negative to HIV, which means their low CD4 levels are cause by something other than HIV. HIV is not the only thing that lowers the CD4 levels.
Low CD4+ T-cell counts (CD4 counts) are associated with a variety of conditions, including many viral infections, bacterial infections, parasitic infections, sepsis, tuberculosis, coccidioidomycosis, burns, trauma, intravenous injections of foreign proteins, malnutrition, over-exercising, pregnancy, normal daily variation, psychological stress, and social isolation.
Low CD4+ T-cell counts (CD4 counts) are associated with a variety of conditions, including many viral infections, bacterial infections, parasitic infections, sepsis, tuberculosis, coccidioidomycosis, burns, trauma, intravenous injections of foreign proteins, malnutrition, over-exercising, pregnancy, normal daily variation, psychological stress, and social isolation.
then could you pls explaing how they intially identified 299 seronegative people out of 230,179 and reclassified 2 of them to Idiopathic Lyphocyte condition after Virus DNA tests.
Teak Please clarify,
CDC initially reported people with AIDS having lower CD4 cells without any HIV infection as in the article said. That means there are some cases concluded AIDS without checking HIV virus or antibodies in CDC reporing system in the earlier days?.
CDC initially reported people with AIDS having lower CD4 cells without any HIV infection as in the article said. That means there are some cases concluded AIDS without checking HIV virus or antibodies in CDC reporing system in the earlier days?.
That article tells you that you don't have to have HIV to have a low CD4. It doesn't have anything to do with what Thankful613 posted.
Here is the original article. http://content.nejm.org/cgi/content/full/328/6/373
The original report published at .http://www.niaid.nih.gov/Factsheets/evidhiv.htm.
I just confused can anybody conform is this survey says initially they have diagnoseed aids with antibody assay and later on during the survey they checked antibodies in all patients listed out here. This is the survey conducted to proove HIV causes AIDS.
Pls give your thoughts on this. Also If at end stage of AIDS and could not found antibodies those people will not be dagnosed for AIDS I guess If they checking the antibodies first time. Also this done early 90s.
I just confused can anybody conform is this survey says initially they have diagnoseed aids with antibody assay and later on during the survey they checked antibodies in all patients listed out here. This is the survey conducted to proove HIV causes AIDS.
Pls give your thoughts on this. Also If at end stage of AIDS and could not found antibodies those people will not be dagnosed for AIDS I guess If they checking the antibodies first time. Also this done early 90s.
People with end stage AIDS will sometimes (rarely; in this study it was 1% of people) sororevert and test negative. They will still have the virus but their antibody production is totally messed up. But, it is pretty obvious that they have AIDS because they basically have no immune system left.
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