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Avatar universal

Side effects after PEP completion

Hi all,

I took PEP (Isentress + Truvada) for 30 days, after what I have been told was a low-risk encounter. Whilst taking PEP, I experienced fatigue, brain fog, memory and cognitive impairment. I was perpetually tired, my brain felt foggy; my thought process was really slow, and I had trouble solving problems which I would have easily solved prior to PEP.

I tested negative on a 4th generation HIV test upon completion of PEP. It is now 2.5 weeks after I completed PEP. However, I am still experiencing the same symptoms, namely fatigue, brain fog, memory and cognitive impairment. These symptoms are debilitating, and I am starting to get seriously depressed.

Could these symptoms be caused by the PEP medication? If so, how long do these symptoms last? Has anyone had a similar experience?

It would be great to hear from someone who has gone through the same thing, or someone who can give me some insight on what is happening. I have no one else to turn to.
4 Responses
Avatar universal
What was the risk factor that you were given PEP? Unprotected anal/vaginal sex with a known infected partner?
Avatar universal
Hi, thanks for replying. It was unprotected oral sex and protected vaginal sex with a partner with unknown status.
Avatar universal
Im sure it has been told to you that you never had a risk. Given that you were wearing a condom that did not break. And even without a condom there is only 0.04% chance of getting HIV. And with a condom that is effectively reduced to zero. Anyway expect all your test to be negative test at day 28 and 12 weeks post PEP. PEP has side effects. Work with the physician who prescribed it to you. What your feeling is anxiety mixed with your body's reaction to the drug. Overall you will be fine. Take care!
Avatar universal
Hi Ross I know this is old but maybe you can answer me. I just recently started with PEP but will most likely stop. How do you feel? Did the side effects go away after a while?
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