Aa
Teak or anyone
If a person is tested at 25 days post potential exposure using a HIV pro viral dna pcr would the results be reliable because it is supposed to look for the actual DNA of the HIV virus and not antibodies. And if the DNA is not there could one assume they are virus free. And would viral load tests which look for RNA of the virus be less accurate because of the chance that their viral load was too low for one reason or another or am I confusing topics
also i have alreay paid for the test and just wanted to make sure i was not a victim of a clever sales pitch, but that this test will give me a pretty good indication of things
I understand, your position but unfortunately some people like myself need clinical proof because my status affects more than myself, so I have to be positive, and I am looking for the quickest most reliable method so I can lay in bed at night and quit playing "what if" till the wee hours and then thinking of it as soon as I get up the next day. Sorry to irritate you.
Human immunodeficiency virus-1 infection correlates strongly with herpes simplex virus-2 (genital herpes) seropositivity in South African and United States blood donations.
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Transfusion. 2008; 48(2):295-303 (ISSN: 0041-1132)
Benjamin RJ; Busch MP; Fang CT; Notari EP; Puren A; Schoub BD; Tobler LH; Hogrefe W; du P Heyns A; Stramer SL; Crookes RL
From Biomedical Services, Medical Office, American Red Cross, Washington, DC, USA.
BACKGROUND: In South Africa, human immunodeficiency virus-1 (HIV-1) infection correlates with herpes simplex virus-2 (HSV-2; genital herpes) seropositivity in genitourinary disease clinic attendees. HSV-2 infection may be a marker for risk behavior and/or directly facilitate HIV-1 transmission. The rate of HSV-2 infection in HIV-infected South African and US blood donations was assessed, and whether the infections were correlated in donors screened and found negative for high-risk behavior by predonation interview was questioned. STUDY DESIGN AND METHODS: A total of 625 South African and 393 US HIV-1-infected repository samples previously characterized for longstanding or recent HIV-1 infection were tested with two commercially available HSV-2-specific assays. The prevalence of HSV-2 antibodies in South Africa was further assessed in 106 HIV-1-infected and 106 HIV-1-negative donors matched for sex, race, and donation history, as well as 200 random HIV-1-negative donors. RESULTS: A total of 52.2 percent of US and 69.3 percent of South African HIV-1-infected donations were HSV-2-seropositive. Age, race, and sex were independent risk factors for HSV-2 antibody prevalence in HIV-1-infected South African donors, who were more likely to be HSV-2 antibody-reactive than random HIV-1-negative donors (72.6% vs. 8.5%: odds ratio [OR], 28.6; 95% confidence interval [CI], 14.5-55) or matched donors (71.6% vs. 19.6%: OR, 10.3; 95% CI, 5.4-19.8). HIV-1 infection and HSV-2 seropositivity correlated in white and black populations when analyzed by age group. CONCLUSIONS: HIV-1 infection correlates strongly with HSV-2 seropositivity in US and South African blood donors. Our data describe the characteristics of HSV-2 antibody testing as a surrogate marker for HIV-1 infection and support a facilitating role for HSV-2 infection in HIV-1 transmission.
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Assess clinically focused product information on Medscape.
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Sign Up To Receive
Medscape Best Evidence
Key journal articles ranked for newsworthiness and clinical relevance in each specialty, linked to Medline abstracts.
Transfusion. 2008; 48(2):295-303 (ISSN: 0041-1132)
Benjamin RJ; Busch MP; Fang CT; Notari EP; Puren A; Schoub BD; Tobler LH; Hogrefe W; du P Heyns A; Stramer SL; Crookes RL
From Biomedical Services, Medical Office, American Red Cross, Washington, DC, USA.
BACKGROUND: In South Africa, human immunodeficiency virus-1 (HIV-1) infection correlates with herpes simplex virus-2 (HSV-2; genital herpes) seropositivity in genitourinary disease clinic attendees. HSV-2 infection may be a marker for risk behavior and/or directly facilitate HIV-1 transmission. The rate of HSV-2 infection in HIV-infected South African and US blood donations was assessed, and whether the infections were correlated in donors screened and found negative for high-risk behavior by predonation interview was questioned. STUDY DESIGN AND METHODS: A total of 625 South African and 393 US HIV-1-infected repository samples previously characterized for longstanding or recent HIV-1 infection were tested with two commercially available HSV-2-specific assays. The prevalence of HSV-2 antibodies in South Africa was further assessed in 106 HIV-1-infected and 106 HIV-1-negative donors matched for sex, race, and donation history, as well as 200 random HIV-1-negative donors. RESULTS: A total of 52.2 percent of US and 69.3 percent of South African HIV-1-infected donations were HSV-2-seropositive. Age, race, and sex were independent risk factors for HSV-2 antibody prevalence in HIV-1-infected South African donors, who were more likely to be HSV-2 antibody-reactive than random HIV-1-negative donors (72.6% vs. 8.5%: odds ratio [OR], 28.6; 95% confidence interval [CI], 14.5-55) or matched donors (71.6% vs. 19.6%: OR, 10.3; 95% CI, 5.4-19.8). HIV-1 infection and HSV-2 seropositivity correlated in white and black populations when analyzed by age group. CONCLUSIONS: HIV-1 infection correlates strongly with HSV-2 seropositivity in US and South African blood donors. Our data describe the characteristics of HSV-2 antibody testing as a surrogate marker for HIV-1 infection and support a facilitating role for HSV-2 infection in HIV-1 transmission.
you never seem to answer my questions have I offended you somehow? I just am looking for advice to save me the hours of reading to decipher if what I am doing is going to tell me what I want to know
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