Warfarin (coumadin) is an anticoagulant and works basically by "thinning out" the blood to prevent further clots from being formed. It should not have any effects on structural changes of the heart or vasculature (including the aorta). However, in the event of a rupture (or bleeding of any kind), there is a higher risk of exacerbating the bleeding process, but again, is typically not a reason to discontinue use (especially if it is indicated for another medical condition (i.e. DVT, mechanical valve, etc.).
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