I am a healthy 46 yr old female, chol 205, weight 140, have been taking toptol xl 25 mg for 2 years for palipatations. I have had all the testing and the results were negative. I occassionally get an (episode) as I call them, I had one beer took the toprol 2 hours later and then my heart seems to just flutter for hours. I try to relax but it just feels like I am wired. Can I be having a reaction to the toprol and the alcohol? How long does the alcohol stay in my system? Or could this be an anxiety attack? I rarely drink more than 2 beers a week. I know alcohol will cause the palipations but I usually feel fine before I take the medication. This does not happen often but when it does it is very distressing. Also, when on the treadmill, what would be a target heart rate since the toprol lowers your heart rate? I want to get my heart healthy, I feel this will help control the palipations. Thank you for this site, I feel sometimes I am the only one with this problem. Made me feel better read all the questions ans answers.