I have large vessel disease,small vessel disease and coronary artery spasms. I have had my LAD restented after I had my first drug eluding stent occlude, which caused an AWMI- my last cath showed It was 50% occluded in April. I was having alot of angina then, just awful burning in my chest, relieved by Nitro. Gi w/u completely negative. I was placed on Ranexa-500 twice daily-for 4 months it was like an miracle drug, now in the past week, I have developed the same pain which has required at least 2-3 ntg daily. I know I can up the dose to 1000mg bid, but they think the Ranexa has caused my GI sx causing a 5 lb wait loss which I cannot afford. What happens when you can't take Ranexa anymore ? I know that surgery is not really helpful for small vessel disease ? i am already on 90mg of Imdur daily,coreg,plavix,asa,lasix,k and lisinopril ?