Amitriptyline overdose caused permanent PVCs

[SenseiRebel]

All my doctors tell me it's unrelated, but I've been having my first skipped and abnormal beats of my life after I overdosed on amitriptyline. It started the day after I took too much of the drug by mistake and ended up in the ER with a fast heart rate during the day (160bpm, but it was a SOFT beat, not hard, which I now find strange). How is this possible to still be affecting me? It's been over a year and it's gotten really worse since then. I had a perfectly running heart till the OD. And a few months later I developed constant pounding in the 170s range, which I'm now on atenolol for. Atenolol slows it down, but no help with PVCs. I'd like to add they're positional skips, based on how I'm sitting or moving, or what kind of surface I'm sitting on. I am not accepting that it's not related as it all started during the same day of the OD. Skipping has gotten progressively worse since then, as well as pounding constantly if I don't take Atenolol. I'd like to know how did an amitriptyline OD cause this, and do you know anyone or have you experienced a drug causing permanent damage to your previously normal heart rate and beats? I am being treated like an idiot when I know this drug caused this, but no one believes me but my family. Could it have damaged cells in the heart that only an MP study could find?

[SenseiRebel]

No, I haven't been on anything since the OD. Why would I take it again after the PVCs started. It's been over a year and 2 months now. They tell me it's out of my system, period. That's about all they say. Means they think only arrythmias would occur while it's in my system. Don't know what kind of damage it's done on a cellular level. Could be several cells or a bunch in my heart got sensitized. But they never find any known conditions on my holter or EKG tests and tell me my heart is strong. Picked up PVCs in the ER but they didn't bother to look into it.

I've already googled the hell out of TCA overdose and no mention of long term PVC side effects.

[itdood]

Not sure why the doctors aren't believing you.  TCA overdose affects ANS, CNS, and causes sinus tachycardia and ventricular conduction delay (i.e. you might get PVCs from this).  It can be nasty.  From what I read you were lucky to survive the OD.

TCAs have high cardiovascular toxicity so it's quite possible it did some damage.    Are you still on it?  if you are perhaps that's contributing to the continuation of symotoms.

Search "TCA overdose" on google, you'll find a ton of info on it.  I'm baffled why your doctors are dismissing it.