I am female, 50 and have just been diagnosed as homozygous for the C282 mutation in the HFE gene. Ferritin level is 471. Tests showed no signs of liver or other organ problems - liver enzymes are well within normal limits.I started developing all kinds of health problems around age 45 (5 years after I started using the Mirena IUD and menstruation ceased,which I did not mind). My joints became arthritic and painful, I became easily fatigued and lately could not even jog 2km, which was really frustrating. I could not do 10 push-ups in a row due to weakness and became very injury-prone. I also developed frequent episodes of pSVT, often at night. A doctor picked up the high ferritin level when I went for a comprehensive health assessment recently to try and find out what was going on with me. The bothersome symptoms make sense now. My question: will phlebotomy reverse the weakness, resolve the SVT and halt the arthritis? I do have (hereditary) high BP and take 12.5 mg metoprolol twice a day, which helps with the heart rhythm problem and keeps my BP around 110/75. An EKG and stress test at the health assessment were normal, but I was completely exhausted after 9 mins on the treadmill, even though I exercise 5 times/week and am not overweight. I just cannot get fit! Many family members on my father' side, including my dad, had sudden MI's and died in their 40's and 50's. Nobody has ever been diagnosed with hemochromatosis. I also have factor V Leiden (heterozygous) and I suppose that, combined with an abnormal heart rhythm and hypertension can be lethal if untreated. I just want to get fit and pain-free again - is that possible? I am getting my children tested as well.