NSVT and Fluconzole

[Bromley]

I have recently had an opportunity to take Fluconazole 200mg 1/day for 10 days for a minor skin infection. Some time ago, however, I had a more or less "successful" ablation for WPW (left free wall accessory pathway variety) after which I was left with short bursts of SVT, and short bursts of NSVT. I experience pehaps 3-10 beats of NSVT only occassionaly and I am taking no other medications at this time.  I believe the NSVT is probably monomorphic in nature. I have no history, and no family history of long QT symdrome.

Given the association of prolonged QT with Fluconazole, what would be your thinking about taking this drug in my case? Some possibilities:
1. take an EKG after 3 days of use and have a trained electrophysiologist read it. Stop if the EKG shows increased QTC.
2. do not take the drug at all.
3. take the drug after exhausting all other possibilities.

I am sure there are other possibilities. Anyway, I think you get the idea. Am I at significant risk here, even if I do not have a history of long QT?

[Michael J. McWilliams, M.D.]

Fluconazole does not prolong QT. It inhibits the metabolism of several medications that prolong the QT.  If you are not on any medications that prolong QT, this should not be a problem for you.

http://www.long-qt-syndrome.com/lqts_drugs.html

Thanks for posting.

[Bromley]

Almost forgot.  I am 48, 145lbs, reasonable physical condition, have no real health problems that I know about at this point.