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Stopping Metoprolol while on Zoloft

I'm currently on 12.5mg of metoprolol succinate and 50mg sertraline and my doctor wants me to stop taking the beta blocker. He told me that just stopping it on 12.5 should be ok but I have concerns. I read that taking the two together can cause more levels of beta blocker to be in the system than normal due to how the liver processes both medications. Should I just stop it at 12.5 or should I taper down further to 6.25mg? Anyone else stop taking Toprol XL while on Zoloft? I'm so scared of withdrawal symptoms but every doctor and pharmacist I talk to seem unconcerned.
3 Responses
20748650 tn?1521035811
If the doctor advises you to discontinue you should be safe. As long as youre not discontinuing it on your own you're fine.

12.5 is already the lowest dose prior to cutting it out.
1423357 tn?1511089042
There is no Metoprolol withdrawal symptoms.  There can be a rebound effect, but it depends a lot on what you were taking it for on whether the rebound wouldbe important in your case.  As was said, 12.5mg is teeny tiny.  At the end of the day, there is a minute amount remaining in your body.  I stopped my 100mg dose 2 weeks before my electrophysiology procedure.  My physician instructed me to just stop.  I was fine.  There was some "jumpiness", but it was completely tolerable.
612551 tn?1450025775
I have been up and down on beta blocker.  My cardiologist has never been concerned about changing the levels to test many other issues over the years.  I even undergone a drop from 200 mg to 100 mg and had no side effect... other than a higher heart rate.  I recall being on both of the mentioned medications.  I was not aware of any negative interactions, but I decided to give up on the Zoloft believing I was/am in fact not suffering from depression.  I was rather very sad about the loss of life in my family.
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