I'm on Metoprolol 25mg ER per day for PVCs. My BP went down from 120/80 to 109/70 roughly and resting heart rate from 65 to 55 BPM. I noticed the effect more at the beginning but sort of adjusted after a few weeks. I still feel a little light-headed when I get up sometimes but haven't passed out yet. ;-)
25mg is not a large dose but maybe he is just sensitive to it? I'd ask the cardiologist.
That also happened to me when I was prescribed Metropolol 25mg I had to cut the pill in half and it took me a few weeks to get adjusted to the effects of feeling like I was walking on air,,I now take 12.5 in the morning and 12.5 at night this has helped me alot. Still get the PVC's but not as much
Dr put me on 50mg of Metropolol 2 weeks ago for PVCs/PACs/SVT/NSVT. He told me to only take it at night as the med can have a very sedative effect. Even taking it at night, the first few days I felt like a zombie most of the day. It got better with each day... and low and behold, so did my arrhythmias! I barely feel them anymore! And each day on the med is getting easier and easier. I'm still a bit tired for the first part of my morning, but I'll take it any day over the non-stop PVCs I was experiencing. Hope things get better for your husband soon!
With some idea of the plasma half life of Metoprolol, and the dose strength, there is technically a small amount remaining. So to answer your question directly, yes, there is a cumulative buildup with each dose. But at that strength, it would take "forever" to build up. For some, the initial dose takes some getting use to. I've been on 75mg. for years, and feel no side effects of whatsoever. You should consult with his physician before modifying what he's prescribed for him.
29y/o female. I had a bad reaction to the Metoprolol Tartrate 25mg when I first started taking it. I was getting disoriented and confused. I was falling asleep sitting up and when time I fell asleep I woke up not knowing where I was, what I had been doing or what day it was. I was able to reorient myself after about 5-10 minutes. My Dr. had me cut (on the score line) the 25mg pills and take a half a one twice a day for 3-4 weeks, then go up to the original dose. Since then I've been fine. It just takes some people's bodies longer to adjust so I'd recommend asking to halve the dose for a few weeks.
This is for those who take Metoprolol. There are two type of Metoprolol, Tartrate and Succinate. With Metoprolol Tartrate, you take it twice a day, usually 12 hours apart. Maximum plasma levels occur about an hour after taking in and it begins to be metabolized. Typically, the dose is reduced 50% every 4 to 5 hours. This is why it's taken twice a day. Metoprolol Succinate is the time release version. It's taken once a day and is slowly metabolized throughout a 24 hr. period. There is a cost though for this "luxury" though as this version is many times more expensive than the tartrate. I take Metoprolol Tartrate, and it's literally pennies per dose. So if you can remember to take your meds twice a day, Metoprolol Tartrate is much more economical. Speak to your physician if you want him or her to prescribe the cheaper version.