17 years to clear HBsAg with Tenofovir, original post with source here

[ShawshankHK]

Below is an old post from Stef, this is the post that calculated that it would take 17 years to clear HBsAg with Tenofovir and 63 years with Telbivudine. I am just reposting so that more people get to know it. Thanks to Stef for having found it.

Address of old post, with more discusstions:
http://www.medhelp.org/posts/Hepatitis-B/tenofovir-has-fastest-hbsag-decline-than-other-nucs-hbeag-/show/1941070


Below extracted from Stef's old post:

http://onlinelibrary.wiley.com/doi/10.1111/liv.12091/abstract

Kinetics and prediction of HBsAg loss during therapy with analogues in patients affected by chronic hepatitis B HBeAg negative and genotype D

Lucio Boglione†,*, Antonio D'Avolio†, Giuseppe Cariti, Gabriella Gregori, Elisa Burdino, Lorena Baietto, Jessica Cusato, Valeria Ghisetti, Francesco G. De Rosa, Giovanni Di Perri

Abstract
Background & Aims
In patients affected by chronic hepatitis because of HBV infection, long-term suppressive therapy with nucleos(t)ides analogues in the HBeAg− patients has shown low effects on HBsAg titre (qHBsAg) decrease, and HBsAg loss is difficult to achieve. Thus, in this type of patients the main goals of antiviral therapy is the suppression of HBV-DNA and ALT normalization.

Methods
We retrospectively evaluated different qHBsAg kinetics in 134 treatment-naïve patients having the same characteristics: HBeAg-, infection sustained by HBV genotype D and persistently undetectable HBV-DNA. Patients were treated with NAs therapy (lamivudine, adefovir, telbivudine, entecavir and tenofovir) for at least 2 years. qHBsAg was performed every 6 months.

Results
Our results showed a significantly greater qHBsAg decline after 2 years in patients treated with tenofovir (0.45 logIU/ml) than in patients treated with telbivudine (0.12 logIU/ml; P < 0.001). The calculated expected time to HBsAg loss was shorter in the tenofovir group than in the telbivudine group (nearly 17 vs 63 years, P < 0.001).

Conclusions
HBeAg negative patients infected by HBV genotype D should be treated with more potent NAs such as entecavir or tenofovir to obtain a significant qHBsAg decrease, but the achievement of HBsAg loss seems to require almost two decades of therapy.

[joc2011]

i will be 3 years on tenofovir this April 2014. And i plan to add on Interferon as a combo. This seems the way forward!

[mer971]

Hi my friend, Steff is saying that it takes 17 years only mono,but it takes only few maybe 5 years to clear it with combo, he is the only one who give hope in this forum and saying  what's going on with new research