Antifibrotic Regimen From gauf's Journal

[zellyf]

HRs' Liver Lover Supplement List
Jan 09, 2008 05:34PM

Supplements as of 1/1/08

I have added links if additional info wanted.

a multi vitamin/no iron

1000 mg of Salmon Oil (epa=160 mg / dha=240 mg / omega 3 = 400 mg) x1

1000 mg of Flaxseed Oil (ALA/omega 3 450 mg / omega 9 110 mg) x1
Raw flaxseed/ 1 teaspoon daily

Hepatapro PPC (900 mg) x 2
info:  http://www.medhelp.org/posts/show/346752  ;


Resveratrol (500 mg) x1  and x2 (alternate every other day)
info:   http://www.lef.org/resveratrol/
source:   http://megaresveratrol.com/


NAC--(n-acetyl-l-cysteine) A sulfur compound that is a precursor of glutathione and protected sulfur-containing amino acid  (600 mg) x2 with Vit C (500 mg) x2
Info:   http://tinyurl.com/9yopf

TMG (750 mg) x 2
http://www.raysahelian.com/trimethylglycine.html

Taurine (500 mg) x 2
In a double-blind, randomized study (3), acute hepatitis patients were given taurine in the amount of 4 grams 3 times a day after meals. The participants in the taurine study experienced significant decreases in bilirubin, and total bile acids.

Life Extension Super Curcumin W/Bioperine 800Mg 60 Caps (800 mg) x 2  / Powerful Antioxidant Properties to scavenge free radicals
Anti-Inflammatory Actions
Enhances important detoxification enzymes Curcumin increases the secretion of bile by stimulating the bile duct. It also protects the liver by detoxification, stimulating the gall bladder and scavenging free radicals. With the help of the adrenal glands, it inhibits both platelet aggregation and the enzymes which induce inflammatory prostaglandins. Curcumin may also help break down fats and reduce cholesterol. Large doses not recommended in cases of acute bilious colic, obstructive jaundice, painful gallstones, and extremely toxic liver disorders



Sylmarin (425 mg) x 2 / Milk thistle provides hepatocellular protection by stabilizing hepatic cell membranes.

Green Tea Extract (300 mg) x 2 /
info:  http://tinyurl.com/ypdp9q

Coq10 (200 mg) x 1 / http://tinyurl.com/29em8c


Colon complete complex contains:
Fiber complex (2000 mg) x2
Lactobacillus F19 probiotic (14 mg) x 2
Lactospore prebiotic (20 mg) x2

I use Smartbomb.com as a source except for the Resveratrol.

I will go with Inulin and Lactobacillus GG when I use up what I have.

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What to take while on tox per HR

The supplements while on tx question is difficult, because the ones having antifibrotic promise are almost all antiinflammatory, somewhat reducing the initiating events at the dendritic cell/lymphocyte interface.I know this sounds technical. Most of them also have, paradoxically an improving effect on some aspects of lymphocyte function, as the spectracell test clearly shows.

Bottom line, NO CLEAR ANSWER possible  regarding  use during tx.

But a moderate use of NAC/VitC, TMG, ALA ( those are quite cheap and possibly  PPC (since it was actually shown to help the SVR rate) is probably a good idea even during tx. Vit D3 is good, but it would be best to know ones serum level.
Also some Inulin is inexpensive (http://www.raysahelian.com/inulin.html) and a very good well researched prebiotic.   Cannot get Lactulose here in the US  without script.  Available w/o script in Canada. Inulin is the alternative.
-------------------------------------------------------------------------------------There is no fundamental difference between pre tx and post tx antifibrotic measures, except that once you are SVR you can hope/expect the profibrotic inflammatory process in the liver to slow down or in the balance with the constant removal of some fibrosis to tilt towards reduction by itself.

The diet principles of small volume, high fiber meals to reduce the metabolic stress on the liver, removal of adipositas and the principle of prebiosis/probiosis/eubiosis apply always before any "supplements" should be taken.
The glutathione replenishing Sulfur containing NAC, ALA, Taurine and SAMe, possibly if affordable combined with actual glutathione  ( some will be absorbed and the rest will supply building blocks) are good starters for liver protection. TMG also tends to improve liver metabolic performance, since it supplies the Methylgroups needed in numerous biochemical reactions.  What you already take is fine too, many of these "supplements ' work in concert and while there are many studies on cells and animals, there are few human trials, since nobody will want to pay for these.

[zellyf]

bump

[meki]

Excellent list...


Just FYI - a lot of this stuff is available at your typical WAL MART... etc.

So - just check it out.

[zellyf]

bump for Ann8

[zellyf]

One comment: the curcumin formula that was discussed was "Super Biocurcumin" and not the super curcumin with biopreine.  gauf may have had a reason for opting for the latter.  

Here is HR's input on curcumin:

http://www.medhelp.org/posts/show/388608

More from HR on other antifibrotic therapy:

http://www.medhelp.org/posts/show/346752