Aa
Aa
A
A
A
Close
Avatar universal

Any Idea or comment to the new Replicor PR

Replicor successfully confirms NAPs target Hepatitis B subviral particles

MONTREAL, April 4th, 2022 – Replicor Inc., announced the successful confirmation of the targeting of Hepatitis B subviral particles (SVP) by NAPs in its REP 301 and REP 401 clinical studies.

Clearance of SVP during therapy is required to achieve functional cure of HBV; circulating HBsAg is comprised of >99.99% non-infectious SVP, which prevents immune control of infection.  Efficient clearance of SVP in the clinic can be confirmed by the selective decline of the small isoform of HBsAg (S-HBsAg), which is uniquely enriched in these particles.

In a new analysis published in Hepatology Communications (here), performed in collaboration with Abbott Diagnostics, rapid clearance of HBsAg during NAP-based therapy of HBV monoinfection (REP 401 study) or HBV / HDV coinfection (REP 301 study) was accompanied by selective clearance of S-HBsAg.  These results confirm the efficient clearance of SVP by NAPs in human infection, consistent with the selective inhibition of the assembly and secretion of SVP by NAPs observed in previous in vitro mechanistic studies here and here.
2 Responses
Sort by: Helpful Oldest Newest
Avatar universal
this goes on to confirm replicor combination with pegintf or zadaxin and tdf or etv is the best hbv cure available since many years but i dont see any interest in making it available...i hope they can make a subcutaneous or intramuscular injection available somewhere in the world
Helpful - 0
Avatar universal
Exciting times in my opinion. With a safe cure and an effective vaccine we could see an end to hep b in our lifetime.

The challenge is making both accessible to all.
Helpful - 0
Have an Answer?

You are reading content posted in the Hepatitis B Community

Didn't find the answer you were looking for?
Ask a question
Popular Resources
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.