Is it just like TDF/TAF/ETV? Or does it do more for us?
NVR 3-778 is a capsid formation inhibitor. The hbv core protein produced during hbv replication is used to a form a capsid, inside the capsid containing the pgrna, reverse transcription takes place. NVR 3-778 disrupts the formation of the capsid, without a properly formed capsid, new virion cannot be replicated. TDF/ETV inhibit reverse-transcription taking place inside the capsid. So all of them target the replication process. If successful, it will lead to reduction of hbvdna in the serum.
Just my layperson understanding.
i found in their website that it's suppose to also provide greater and faster suppression of cccDNA and possibly also reduce HBsAg levels