Here the advise from my doctor regarding this topic - continue with the current medication Viread (tenofovir), monitoring laboratory tests every 6 months including creatinine, if the creatinine were to persistently increased by 0.2 or greater we can change to Vemlidy, TAF. Did you have kidney problem before starting Tenofovir? No worries as this will not resolved any problem... And everybody is different. We'll all react to this medication differently. If you read the old posts, they are several people who have been on Tenofovir for years... Just follow your doctor advise and keep monitoring your labs.