the only first line drugs for hbv are: tenofovir (most potent, no resistance), entecavir (resistance very high on lamivudine users so it cannot be used if not naive to treatment), peginterferon
many years of tenofovir (3-6years) and then peginterferon add on are showing 50% cure of hbv by 1 year of combo, al low hbsag less than 1000iu/ml is a good time to add on peginterferon to clear definitively in more cases
no antiviral can cure hbv infection they can only lower virus replication and liver damage
lamivudine is out of guideline since a longtime because it makes extremely dangerous virus mutations even not treatable in some cases of hbsag mutations