Chronic Hbe negative HBV for 14 years.. Now raising its head?

[wishful01]

(reposted..)

My hbe neg- hbv, has not been showing itself recently in LFT and HBVDNA numbers or u/s or F'scan: (ALT less than 35 for last 3-4 months-has remained between 19 and 44 in last 7-8 months. And hbvdna that was 28,500 cop/ml in July, is UND since September, 2012-checked twice).

However, the news is that:
a) my cholesterol numbers are getting bad. Total cholesterol is 5.5 against max limit of 5.2, LDL is 3.8 against max limit of 3.4, and HDL is 0.99 against min of 0.9.
b) Prothrombin time was 14 sec in Sep, 12 (lab limit 13). Now it is 15 sec. INR is 1.1.
c) Most importantly, kidneys: Creatinine has reached 114 umol/L (upper limit 124), and uric acid is 465 umol/L (limit 420).

This is a dilemma. If I try to control my cholesterol, that might make blood  thinner which will further increase Proth. time. Also how to manage RFT (Uric acid and creatinine)?
I am not taking any medicines etc now. Just green tea 1/day, and honey in warm water 1/day. I am a thin person, and have started walking 2-3 km a day recently.

So what advice do you have please? Does it have to be an antiviral now? with hbvdna und and ALT in and around 30s? Could that be even useful?

(I am thinking to re-start vit D: had stopped it earlier after taking for 2-3 weeks as i thought it is making my kidney function go down, but even after stopping it, the RFT values are still going slightly up instead of down. I am still going to monitor RFT, and calcium). One thing: they say stress can elevate chol. And I have been stressed lately, maybe that explains the cholesterol part.

Thank you very much.

[wishful01]

http://www.genomeweb.com/rnai/arrowhead-cleared-begin-phase-iia-trial-hbv-drug

Arrowhead Cleared to Begin Phase IIa Trial of HBV Drug

Arrowhead Research this week announced that it has received clearance from regulators in Hong Kong to begin a phase IIa trial of its siRNA-based hepatitis B treatment ARC-520.

The single-dose, dose-escalation trial is designed to determine the drug's ability to suppress hepatitis B surface antigen in combination with the oral antiviral agent entecavir in chronic HBV patients.

Single doses of ARC-520 will be evaluated at up to two ascending doses of 1.0 mg/kg and 2.0 mg/kg, Arrowhead said. At each of the two dose levels to be evaluated, a cohort of 8 patients will be enrolled with 6 being dosed with ARC-520 and 2 being dosed with placebo.

With the regulatory approval in hand, Arrowhead said it expects to begin dosing patients "shortly," and that top-line results from the study will be available in the third quarter of the year.

[wishful01]

Thanks.

1. Any comment on my HBsAg that has come down from around 2600 to around 1800 in about 10 months?

2. What important factor made you start antiviral since you had HBVDNA und and had got cirrhosis under control using heptech products?

[stef2011]

dont worry about gcmaf, too expensive and only available by gcmaf.eu or saisei japan, useful only if nagalase is so elevated to make immune suppression

to test it you need to ship frozen  blood to redlabs.com or http://www.europeanlaboratory.nl/

so it is difficult, you also need a lab to draw blood and ship frozen with dry ice or proper type of shipment.i mean if you are at very high risk for hcc it makes sense to test it

[wishful01]

Nagalase monitoring is not available in any hospital / lab of Pakistan that I have checked online or visited. Also, gcmaf for treatment seems to be not available. Are these very special/expensive? An idea about gcmaf's price?

Can any member tell me if gcmaf is avl in India or UAE.

[wishful01]

Fibroscan History / latest: Have had total 3 so far: Went for the first one in Sep, 2012 after the temporary re-activation of my old inactive HBVDNA : result was 3.3. I started vit D3, green tea and all the diet care (exclusions) as you advised me. After about 5-6 months, the repeat Fib result was 4.4. I continued with the same diet etc and thank God, in Dec, 2013 I was again at 3.3. (Fibroscan responds late?)

HBsAg Quant (Abbot Architect): Done 2 times so far. In Feb, 13 it was 2674. Recent, in Dec, 13 it is down to 1820.

Kidneys: taking baking soda (less than advised though, as more gives me upset stomach). Kidneys have shown slight improvement (creatinine remains less than 100)

HBVDNA last checked in Nov was -. Has remained negative last one year.

I have noticed a trend of liver area (and under ribs) pain. It comes for few days and then goes away on its own. Started again yesterday, intermittently- is bearable though.

My last u/s was ok. hemangioma size etc remains same. AFP last checked in Nov: is just within limit.

Any comments?

Question. You are HBVDNA- too. What made you start antiviral? Good to avoid HCC risk?
HCC is really scary, but I cannot increase D3 intake (current 5000) as it tends to increase serum Calcium. Will go for D3 test end of the month, but I am sure it would be just around 40 or so going by my previous trend. Will post result.

Thanks

[stef2011]

Thanks for the advice. CoQ10 was once advised by you for helping my kidneys, but I am convinced now its better to avoid it for now.

yes it is very helpful maybe brands like solgar can declare where it is from

1. I think I cannot try fish oil because it thins the blood. Because my PTT had gone upto 15 sec, but I repeated (at a better lab) after 2 months and it showed 12.9 sec.

i think you are getting messed up by the methods and range:
PT norm range 12-15sec
APTT <40sec
PTT 0.8-1.2 but this is not in seconds

if you take vit k1 you get normal factors but i dont think they are abnormal