On the contravir website one can find original data on the hbv inhibitory capacity of crv431. It is modest. But it is certainly a totally different, likely synergistic, mechanism to the polymerase inhibitor drugs.
The cyclophilin are abundant cyclosolic proteins, with several not fully defined cellular functions. Inhibiting them might be dangerous and prone to serious side effects. Thus we have to await the results of human studies to allow any judgement re the usefulness of this compound in hbv therapy.