i can t say it regresses fibrosis but i think all these supplements do help.the results of several studies indicate:
effect fatty liver, cardiovascular health, sugars/lipids so this can also reflect on less fibrosis development
yes it is, it is the only puritan with dha and epa quantity with enough quantity for us but you have to take 3 pills per day to reach enough
Stef, do you know is high EPA and dha can actually regress fibrosis?
This is what I use, very high in EPA and dha.
http://www.pho.it/popup.asp?prodottoID=202
Hi Stef,
Can you confirm this is the product you are refering to?
Puritan's Pride
One Per Day Fish Oil 1360 mg
950 mg / 90 Softgels
http://www.puritan.com/fish-oils-056/one-per-day-fish-oil-1360-mg-032948
Or if you know other brands that are more effective that you can recomend.
Thanks a lot
Blackadar raises the question whether high intake of marine products containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may partly explain the low incidence rate of hepatocellular carcinoma (HCC) found among HBsAg-positive individuals in our population-based cohort study in Greenland.
Although EPA and DHA appear to have protective effects against cardiovascular disease (1), firm evidence of protective effects against cancer is lacking (2). Conflicting results have been published on the association between n-3-fatty acids and HBV/HCC. However, recently Sawada et al. concluded that consumption of n-3 fatty acids (in particular, EPA, docosapentaenoic acid [DPA].....
there is another study that confirms effectiveness of EPA, DHA against HCC
Hepatocellular Carcinoma and Other Liver Diseases Among Greenlanders Chronically Infected With Hepatitis B Virus: A Population-Based Study
http://jnci.oxfordjournals.org/content/early/2012/08/21/jnci.djs361.extract#
Cannot copy from there.
Found a study on Omega-3 and HCC
Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma.
Abstract
BACKGROUND
Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known about its association with hepatocellular carcinoma (HCC).
METHODS:
We investigated the association between fish and n-3 PUFA consumption and HCC incidence (n = 398) in a population-based prospective cohort study of 90,296 Japanese subjects (aged, 45-74 y). Hazard ratios and 95% confidence intervals (CIs) for the highest vs the lowest quintile were estimated from multivariable adjusted Cox proportional hazards regression models. We also conducted subanalyses of subjects with known hepatitis B virus (HBV) or hepatitis C virus (HCV) status, and of subjects who were anti-HCV and/or hepatitis B surface antigen positive. All tests of statistical significance were 2-sided.
RESULTS:
Among all subjects, consumption of n-3 PUFA-rich fish and individual n-3 PUFAs was associated inversely with HCC, in a dose-dependent manner. Hazard ratios for the highest vs lowest quintiles were 0.64 (95% CI, 0.42-0.96) for n-3 PUFA-rich fish, 0.56 (95% CI, 0.36-0.85) for EPA, 0.64 (95% CI, 0.41-0.98) for DPA, and 0.56 (95% CI, 0.35-0.87) for DHA. These inverse associations were similar irrespective of HCV or HBV status.
CONCLUSIONS:
Consumption of n-3 PUFA-rich fish or n-3 PUFAs, particularly EPA, DPA, and DHA, appears to protect against the development of HCC, even among subjects with HBV and/or HCV infection.
i think not, during a flare you need inflammation
Alt reduction only is not a goal isnt it?
no, alt normalization is a goal only after hbsag und or in case of severe liver damage, the aim of damaged liver/cirrotic livers is reduce damage to zero
Is it a good idea to add polyenylphosphatidylcholine (EPA, DHA) as supplements when on INF treatment or when hbsag goes down on alt flare?
Can not find any research on it. Only found that it normalize alt but no info on what it does with hbsag.
Alt reduction only is not a goal isnt it?
if your hbsag is so low as 12.8iu/ml you alreadyhave an immune response going on and tdf add on will probably make it weaker in your case, so i d go for peginterferon possibly plus ezetimibe or nitazoxanide but even peg alone will clear in your case
only if your hbvdna is very high tdf add on makes sense, otherwise go for peg intf alone
Hello Stef, hope you are keeping well. I have been taking the Italian long life fish oil for about 6 months now and have just ordered more. Very encouraging to read this and all of us HBVers should really be taking this especially those like me who have fibrosis with a fs reading of 8.7kpa. Btw, u go back to doctor in London at end of march to have hbs checked again to see if it has dropped below 12.80 iu/ml. Will ask about trial of tdf and ifn in uk when i am there.
thank you so much for your post, we have a research that finally indicates doses for liver which are about 2-4g, i already used these high dosages.most products on the market have no such doses, i have found only two with such high doses
puritans "one per day formula", i take 3 pills per day, they contain EPA 625mg and DHA 244mg.3 pills equal epa 1.87g dha 0.7g about 2,6g daily.180pills 25usd and 450pills 50usd
this is expensive but has the highest epa dha content, only in liquid form:
5ml, epa 1.8g dha 0.9g equal to 2.7g.the cost is 35€ (47usd) and once open it must be consumed by about 30-40days and kept in fridge
please post if you find better products, of course these oils must be purified from metals