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GS 9620

any special report for the medicine of GS 9620 giland
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What might b the cost for it, Cuban vac? Any valid assumption ?
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Our all hope is from Cuba as they are still virgin & didn't merge to the big pharma cartel yet.
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Omg such big scams and plans behind the business these company do, this way hbvers future will remain dark. Dreams shattering infos. Certainly the motive of FDA and govt are to fetch money by treating and no cure, peg is a noble example being expensive having big side effects low response rate yet approved. Replicor cud try getting approval from other countries apart from us. Anyways don't know much of these policies. Feeling helpless.
Thanks for the infos Steff and Stephens.
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It is because such big companies are allowed by laws that we dont get products like replicor from small companies, whcih is the only one with curative potential in combo, on the market

there really is a pharma mafia cartel so potent that they can push drugs with disappointing results when there are potential cures......i mean they are so sure replicor will never get the market to go on and pay high costs for fda approvals on disappointing drugs.

We need more competition from small companies  and laws should get them cheap approvals otherwise it is all just a cartel
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Gilead may be a big company, but I think its executive pays and shareholder interests come before patients'. Look at the way it prices its HCV drugs.

The phase 1 clinical trial results of GS9620 on HBV patients were disappointing to us laymen, especially when compared to the results for the chimps. However, most experts seem to think it should be further developed for it is now in phase 2., still with very low dosages, and proceeding ever so cautiously(as in slowly)..

Just my opinion.
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Stephen gilead sciences is a big company unlike replicor so I think it will come out with something certainly, do u know something positive, like other subjects  gs9620?
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Alas! One amongst the rare hopes shattered. The trials were running from 2013 and it took 2long years wait to announce failure.
Thanx for the info Stephen.
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GS4774 had reported its clinical trial results. Basically, it seems to have failed its expectation at its primary end point. As a result, the company, GlobeImmune, saw a dramatic fall in its share prices, had retrenched half its staff to preserve funds, and is considering its future. There is no words from Gilead whether it will continue to fund the development of GS4774.

This is one of the "unexpected" failures in 2015, very disappointing, considering the therapeutic vaccine consisted of both s and c antigens and was funded by Gilead.

https://www.globeimmune.com/press-releases/globeimmune-announces-top-line-results-from-gs-4774-phase-2-trial-in-virally-suppressed-chronic-hbv-patients/
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Gs 4774 was to complete phase 2 in 1st half of 2015 yet no news?
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It's becoming irresistible waiting n waiting and feeling helpless when nothings working. Peg failed tdf zadaxin all waste. 2015 is a modern tech world now but still we r helpless.
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when can expect the medicine will come in the market and it is better to compare the tenofovir and it can be used for chronic and acute as well as  cured full of hep B virus ? when the Hongkong tril will be happen?

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but they (replicor) can give very tough competition to others.so somehow we have to support them.
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Well if Replicor cares then why nobody from them ever comes to these forums and talk to us?

There has got to be a better way about going these trials.
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perhaps stef is talking about immiquimoid aldara. not about gs 9620. gs 9620 is from same class as immiquimoid tlr 7 receptor but it has some serious chemical differences with immiquimoid, specially  a straight chain in the structure.
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nobody cares about us. but my friend we have to make that nobody somebody. and that nobody may be replicor.
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Stefan. Are you saying that GS9620 wont work? Better stick with pegasys?
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all government funding must be stopped, all of this should be given to nasa's biologists. they are more scientific and innovative than these traditional fundamental research institutes which are tightly  in hands of greedy and incapable people whose only  work is to absorb and stop talented people from doing anything for society by using beauracratic and management powers.untill all these people are not taken out from research institutes listen guys nothing is going to happen.put your voice in your country specially usa people,as things are listen in that country and it has enormous potential to find the cure of hep b.
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It is not the company culture per say. It is the whole corrupted system that all this thrives in.  If you have sales - marketing people recruit patients for them for trials via like a brokarage firm. What else is there to say about company culture.

It would be much simpler to distribute this medicine through local hospitals and let patients doctor monitor the patient locally.  Rather then one have to drive 70 miles or more each way while on this stuff.

Nobody cares about us. Nobody.
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cant be use less than 12.5 or dose which can be tolerated easily. though it will generate low levels of interferon, if consistant then even this low interferon may be useful.as its our own. and after all something is better than nothing.
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does anybody know history of trial times in different phases,needed by gilead hep c drug Sofosbuvir (formerly PSI-7977 or GS-7977) to go in advance phases. by this we can guess time needed by gs 9620 which is for hep b. though time wont be the same but it gives a clue about company culture.
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yes imiquimod as therapy is out of question for now and results have been very limited, i guess the problem is that imiquimod should be continued daily as 12.5mg suppository or higher but sides are absolutely not tollerable (fatigue, blured vision, creatinine increase, heavy general inflmmation, hair loss and change from straight to curly), at least for me, and this cannot be done.while if we use imiquimod every other day or less the production of interferon is not continuous and results are none

i ll be making pegintf add on soon and i believe peg could be better because pegylation allows a steady interferon level even if lower than imiquimod, we will see what results can be achived
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better than wait is disscuse immiquimoid aldara as therapy.
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they should just give it out now.

We have to demand it guys. Not only this but demand better more open clinical trials, that involve more then just six people.

The way they run clinical trials is very tricky. Clinical trial recruiters act like sales people. They take only certain people, and don't really explain anything. I am so disappointed. It seems like if you ask one wrong question, or ask too many questions,  they wont take you. Asking too many questions raises alarm that you may be an educated patient :)))

Seems like they need people who have no clue what this is. And there is plenty of those.

I am telling you guys, it is so jaw dropping sick to see what has become of medicine today. :(((((

https://www.americanbar.org/newsletter/publications/aba_health_esource_home/Rusczek.html

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stef is thinking of making a  trial of tlr7 compound immiquimoid under expert supervision from france in future which is from same class as gilead's gs 9620. whose results will be available much before gs9620. actually stef told it is available as aldara cream but has no standard method to consume and has many sides.
djxpress may tell more about gs 9620. it makes our body to make our own interferon and in more quantity with less side effect and may be very useful in curing hepb with antivirals. perhaps will be available in 2017 when gilead's tenofovir patent is going to end.
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