GcMAF and activation of macrofages

[stef2011]

an italian well know researcher is making research on GcMAF with yamamoto.

of course if this work no drug maker will ever produce this drug and US will go bankruped

but we are lucky anyway because it is in everybodies blood like immune globulins, so no sides, no patentable, no high cost and especially no trials needed to check safety or for its use.if it works it would make US bankruped

http://www.gcmaf.org/

belgium production
http://www.gcmaf.eu/info/

israel production
http://pps.co.il/

[stef2011]

for those who can:
test your nagalase level, it might show immune suppression and if present this explains cronic hbv

the test is not expensive, about 65euro, so we can understand how nagalase level correlates with hbv.blood samples can be sent at this laboratory but since they might be in dry ice pack the type of shipment must be fast

in europe:
http://www.europeanlaboratory.nl/

in US:
contact the lab for indications where to do it in US

[nimrodken]

If Hep only needs to be Quarantine and our human body just need to be healthy doest in mean that with the help of these kinds of drugs hep B can be eliminated? My doctor always reminds me to be healthy bec. sooner or later drugs is ready to all... It needs a deeper research and funds for that.... but who knows... may be tomorrow ....

[stef2011]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC39321/pdf/pnas01511-0079.pdf

The results of this study demonstrate that hepatocellular
HBV replication can be abolished by noncytopathic, cytokinedependent pathways activated by an unrelated viral infection
of the liver, even when that infection is principally limited to
a different cell type, in this case the macrophage. This suggests
that the induction of cytokine activity within the liver by agents
(viral or otherwise) that activate resident macrophages or
other cell types to produce these cytokines may have therapeutic value in chronic HBV infection.

so this should mean that if we activate macrophages hbv gets cleared without damage or relevant alt flares

[stef2011]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC39321/pdf/pnas01511-0079.pdf

i found this study that shows how hbv clearance is medited by macrophages without liver damage, if nagalase happens to be elevated during hbv infection macrophages are inactivated and this might be probably the reason and the key to get rid of hbv

[StephenCastlecrag]

"http://hbo-kennisbank.uvt.nl/cgi/av/show.cgi?fid=5022"

Very good paper by a PhD student. Immunology is so complex, so many inter-relationships, you need to be a full professor to understand it all. So many things can influence the immune system, where do you start? Good luck with Gcmaf.

[stef2011]

in conclusion the studies confirms that macrophages impairment (probably by hbv or by hbv increasing nagalse who knows...) and dentric cells impairment (dentric cells respond to macrophages that present hbsag) might be the reson of no immune response on cronic hbv

there is also a part which talks about macrophages and hbsag but i haven t got it clear, what i suppose is that activated macrophages by gcmaf express a lot of receptors, among those also TLR receptors, get hbsag (don tknow if single hbsg antigen is needed or all virus) and then present that to dentric cells which give permission to t cells specialized on hbsag to duplicate and make a lot of hbsab

the only fear in my hypothesis is if macrophges need the full virus to digest and present the single antigens to dentric cells or if even single hbsag are enough to start immune response
this would be a big problem on tenofovir or entecavir therapies, since both decrease circulating virions and so decrease immune response too even in the case of using gcmaf