GcMAF and activation of macrofages

[stef2011]

an italian well know researcher is making research on GcMAF with yamamoto.

of course if this work no drug maker will ever produce this drug and US will go bankruped

but we are lucky anyway because it is in everybodies blood like immune globulins, so no sides, no patentable, no high cost and especially no trials needed to check safety or for its use.if it works it would make US bankruped

http://www.gcmaf.org/

belgium production
http://www.gcmaf.eu/info/

israel production
http://pps.co.il/

[stef2011]

http://www.gcmaf.co.uk/info/

sorry forgot to say name of the italian researcher, marco ruggeri in florence, he is often out of italy for work but i will try to talk to him next time i am in pisa for check up visit

i paid very much interest to this because marco ruggeri is very well known and serious researcher.i read some of his research and looks very balanced and also my doctors know him

[jonny168]

wow! i hope they test this on hepatitis patients. this looks promising.

[stef2011]

i got a response from GcMAF producers

I have heard a few physicians say that it is worth a try for Hep. in particular. We do not know if they have tried it yet.
The product works independently. It does not target a specific pathogen, it enhances the immune system, which then can take care of pathogens itself.

[stef2011]

they do supply it also for hbv but i'd use it only with a researcher although it has no sides

[chanthou]

Thank you Stefano for your research for cure.

Are you planning to use this substance to treat yourself? But, in the materials no mention about HBV, only HIV.

I am eager to this medicine workable for HBV.  It is much pain to family to bear this cruel disease.  

Is it expensive? Affordable to low income people?

[stef2011]

i haven t seen prices at about 600euro and free resend of drug if no cancer regression at all happens, the drug doesn t target a disease but immune system which is blocked by viruses and cancers, then it works on any disease with immune system block

i will talk to the italian researcher involved but i plan to use it only if alinia and interferon will fail

[stef2011]

http://www.marcoruggiero.org/pdf/GcMAF%20at%20the%20NIH.pdf

conclusion:
NF kappa suppress immune function and is induced by tumor carinogens and viral proteins of hiv,...other viruses....HBV,HCV

Gcmaf produces NF kappa inhibition, so definitely this therapy, FREE OF SIDES, less expensive than interferon, less expensive than baraclude worths a try

hbv carriers are also at increased risk of leukemia this is probably due to NF kappa

[stef2011]

www.marcoruggero.org
personal website of researcher marco ruggiero with GcMAF info  

usefull links from marco ruggiero website:

Biology at the University of Firenze
http://www1.unifi.it/clsbio/mdswitch.html

Research Institutions

National Institutes of Health degli Stati Uniti
www.nih.gov


National Cancer Institute

http://www.cancer.gov/


La ricerca del Pentagono (comprende la ricerca in biologia)

www.darpa.mil


L’Istituto di Craig Venter (vita sintetica, genoma del pianeta)

www.jcvi.org


Dall’Università dello Utah un sito eccellente e gratuito per la didattica in biologia cellulare, molecolare e genetica. Esperimenti virtuali e dimostrazioni interattive

http://learn.genetics.utah.edu/



Database

www.pubmed.com

http://library.med.utah.edu/WebPath/HISTHTML/HISTO.html

[stef2011]

www.marcoruggero.org
personal website of researcher marco ruggiero with GcMAF info  

usefull links from marco ruggiero website:

Biology at the University of Firenze
http://www1.unifi.it/clsbio/mdswitch.html

Research Institutions

National Institutes of Health degli Stati Uniti
www.nih.gov


National Cancer Institute

http://www.cancer.gov/


La ricerca del Pentagono (comprende la ricerca in biologia)

www.darpa.mil


L’Istituto di Craig Venter (vita sintetica, genoma del pianeta)

www.jcvi.org


Dall’Università dello Utah un sito eccellente e gratuito per la didattica in biologia cellulare, molecolare e genetica. Esperimenti virtuali e dimostrazioni interattive

http://learn.genetics.utah.edu/



Database

www.pubmed.com

http://library.med.utah.edu/WebPath/HISTHTML/HISTO.html

[stef2011]

http://www.diagnosesupport.com/info/index.php?option=com_content&view=category&layout=blog&id=8&Itemid=9

[stef2011]

a lot of studies available at this page

http://www.diagnosesupport.com/info/index.php?option=com_content&view=category&layout=blog&id=6&Itemid=2

[stef2011]

i don t understand,
is Nagalase activity increased for all the cases of cronic cancers and viruses that have immune system blocked?
if so can we test our nagalase activity and our receptors poliymorphisms to see if GcMAF can have a great response on us?

[stef2011]

http://forums.aboutmecfs.org/showthread.php?6019-GcMAF-for-XMRV-Gc-protein-derived-macrophage-activating-factor-anyone-taking-it

this is a thread in a cronic fatigue syndrom forum, they are treating with GcMaf already from 2010 under specialized doctors.it might be useful to see their experiences although this drug might not be effective for them, unluckily CFS has unknow probably viral origin

i see they have reference labs for testing but i think in hbv infection it is not needed, hbsag quantification and all antigens/antibodies quantification might be good enough, while hbvdna and alt must not be considered as a tool to see immune system reaction.
mainly hbsag and hbsab can be used to see that

it is lo menthioned that vitamin d levels must be normal for GcMaf to work

[stef2011]

http://forums.aboutmecfs.org/showthread.php?6019-GcMAF-for-XMRV-Gc-protein-derived-macrophage-activating-factor-anyone-taking-it/page55

somebody used it to clear hcv successfully, i ll try to get in contact with him.in this post there is indication also about best producer.
drug available in europe while US the most difficult place where to take it...(guess what drug companies making issues)

dsp2011  
Junior Member
Join Date
Dec 2010
Posts
5

Just spent hours reading entire tread.

1. Why no one is testing vitamin D3? This is what GcMaf supposed to use to work off, right? So why are you guys running bunch of utopia tests and forget about this one? I can't believe your GcMaf rep didn't tell you to make sure you tan or have enough vitamin D3 in your blood before you start. No vitamin D3 - no macrophages meaning waste of GcMaf...
2. BGLI and any GcMaf that you need to freeze - is not original or real. it may work may not but not original formula. Original formla supposedto be refrigirated at 4-8 celsius and very stable - should be in great shape after 6month and even longer.
3. If you are paying less than $700 a shot you don't have original formula.
4. PPS in isreal is the company that produces it. they don't sell it directly but they do have representatives http://www.pps.co.il
5. Shipping to USA out of question. Ship it to Canada or Mexico to your friends and then pick it up and bring it over the border or fly to Israel or London - they can ship it to london address.
6. GcMaf has side effects, if you don't have any ***** to be you - you are using fake version and wasting money.
7. Friend of mine had great results with HEP C - negative after 8 years of being positive. he took 24 shots.

I don't have any updates on my situation because i just took my first shot and other than a lot of heavy side effects i can't report on anything but will let you know the progress once i have blood work and see numbers, i just hope i will turn out as good as friend of mine! so i keep my fingers and toes crossed :)

[StephenCastlecrag]

Thanks very much for all the references - will put my reading glasses on and start reading.
These immune modulating substances cover a big big field. So far it seems:
1.IL-7 deals with T Cells
2.GcMaf deals with macrophages
Then there are Natural killer cells (NK), Dendrite cells, innate/adapted, humoral/cellular.....
[hope I got it right]

[stef2011]

thank you that's a big help from you because i might miss details sometimes since english is not my mother toungue

i try to read most of cronic fatigue forum posts till late at night to see their experience on sides effects, producers of drug and so on
again i stress we cannot compare their weak/medium results because Gcmaf is not the answer to their disease but might help them find a balance, who knows exactly all the mess of viruses and immune system damage they have

today i will send an email to doctor ruggero to see if they studied anything on hbv too

[stef2011]

yes you are right about il7, the researchers in pisa know doctor andreone who makes italian tiral but they told me last year that there are too many risks for il7 especially because other trilas had severe immunological impairments which came out years after the trial

they say better stay here and watch carefully what happens...

[kc00]

Interesting

[stef2011]

http://www.springerlink.com/content/2186446772066150/


ORIGINAL ARTICLE
Gc protein-derived macrophage-activating factor (GcMAF) stimulates cAMP formation in human mononuclear cells and inhibits angiogenesis in chick embryo chorionallantoic membrane assay
Stefania Pacini, Gabriele Morucci, Tiziana Punzi, Massimo Gulisano and Marco Ruggiero

[stef2011]

http://forums.aboutmecfs.org/showthread.php?6019-GcMAF-for-XMRV-Gc-protein-derived-macrophage-activating-factor-anyone-taking-it/page55

after some troll posts the forum talking about gcmaf has dissapered since 2 days....how strange, you are very good with google are you able to find back this forum?

one researcher in US who was making the gcmaf dyed some years ago and everything was stopped in US research of gcmaf..., are these two coincidences?

i always think for the worst things but anyway where we see something not welcome from drug makers it surely is good to give it a try

[StephenCastlecrag]

Found this at:
http://******.***.com/index.php?topic=33634.0

It seems Ruggiero & Dr Nabuto Yamamoto (USA) are both controversial according to the following posts.

Posts: 14




Controversial Poster Thursday at Vienna Conference:GcMAF
« on: July 20, 2010, 07:10:07 am »

Let us know what you think. Use the new "Reactions" vote at the end of each post, below. Just click the 'Good' or 'Bad' box. (Added July 19, 2010).

July 17, 2010Controversial Poster Thursday at Vienna Conference: Call for Information on GcMAF
by John S. James

We will not be at the big Vienna conference starting tomorrow (International AIDS Conference, July 18-23), and would like to hear from anyone with a scientific background who can visit the poster below, on Thursday, and the presenter.

A separate paper published last year by N. Yamamoto and others (see the abstract and link to full text at http://www.ncbi.nlm.nih.gov/pubmed/19031451) claims to have cured 15 patients in Japan. "In the present study GcMAF therapy was given to nonanemic HIV-infected patients and found to be highly curative."

About 130 peer-reviewed papers related to this work can be found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=19031451. The proposed mechanism seems plausible -- that HIV produces a substance that shuts down immune responses in monocytes and macrophages, helping HIV infection to continue. The treatment appears to restore the response.

The research is controversial because it claims to have cured HIV infection, and also prostate cancer. The connection is not outlandish, however; for example, U.S.-government funded research at Yale is looking at a possible immune-based potential treatment for the same two illnesses (http://opa.yale.edu/news/article.aspx?id=7061).

Also controversial, the poster presenter at the International AIDS Conference, M. Ruggiero, is an accomplished molecular biologist -- but also a leading HIV denialist (Google: "Marco Ruggiero" HIV -- or see his 14-minute lecture uploaded January, 2010, to http://www.youtube.com/watch?v=-Sh03lqTsJw -- or see the abstracts of the denialist conference being held in Vienna on the two days before the International AIDS Conference there, http://www.science-and-aids.org/e/abstracts.html). However, Dr. Yamamoto is clearly not a denialist -- and apparently has not published with Dr. Ruggiero before the Vienna conference starting Sunday.

There are lots of mysteries here. For example, how has Dr. Yamamoto been publishing this HIV work extensively for at least 15 years in peer-reviewed journals, recently reporting excellent results, with almost no attention from most other HIV researchers?

We are concerned because we have heard that funders of research are not seeing new ideas for curing HIV being proposed. But there are lots of ideas, some credible, and no way to know in advance which ones will work out. Many human groups close themselves off and become increasingly narrow in focus, until they are irrelevant. In that case, new ideas cannot come forward. It would be tragic is this is happening in AIDS.

Here is the reference to the poster on Thursday:

THPE00 51 Gc protein-derived macrophage activating factor (GcMAF) stimulates activation and proliferation of human circulating monocytes
M. Ruggiero (Italy), S. Pacini (Italy), N. Yamamoto (United States)
Program of the XVIII International AIDS Conference, July 18-23, 2010, Vienna, Austria, page 306; Thursday July 22.
http://aidsnews.blogspot.com/2010/07/controversial-poster-thursday-at-vienna.html


Gc PROTEIN-DERIVED MACROPHAGE ACTIVATING FACTOR (GcMAF) STIMULATES
ACTIVATION AND PROLIFERATION OF HUMAN CIRCULATING MONOCYTES
M. Ruggiero*, S. Pacini**, N. Yamamoto§
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
**Department of Anatomy, Histology and Forensic Medicine, University of Firenze, Italy
§Division of Molecular Immunology and Immunotherapy, Socrates Institute for Therapeutic Immunology, Philadelphia, PA, USA
http://pag.aids2010.org/PAG/EPosterHandler.axd?aid=6536
« Last Edit: July 20, 2010, 07:19:12 am by Bobitalia » Logged
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Re: Controversial Poster Thursday at Vienna Conference:GcMAF
« Reply #1 on: July 20, 2010, 11:30:51 am »

How interesting.  I have to wonder why anyone who co-author something with Ruggiero who is at best a crackpot and at worst...scum of the Earth.
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Re: Controversial Poster Thursday at Vienna Conference:GcMAF
« Reply #2 on: July 27, 2010, 01:27:45 am »

There are a few things that would make me a bit skeptical here, aside from Dr Yamamoto's association with Ruggiero.

Firstly, Dr Nabuto Yamamoto is 85 years old.*

Secondly, his position is listed as "Division of Molecular Immunology and Immunotherapy, Socrates Institute for Therapeutic Immunology".

The address given for this Institute appears to be a private dwelling in suburban Philadelphia. The Institute has no website of its own. It is registered as a non-profit organization, and has no paid employees.

Internal Revenue Returns (Return of Organization Exempt From Income Tax) show little evidence of much actual research work over the past few years - no more than a few hundred dollars in expenses per year. By far the largest expense incurred by the Institute is "publication costs" in several medical journals.

http://nccsdataweb.urban.org/PubApps/showVals.php?ein=232834414

*I wonder if there has been some confusion with Dr Naoki Yamamoto who is the Director of the HIV/AIDS research center of the National Institute of Infectious Diseases in Tokyo.
« Last Edit: July 27, 2010, 02:25:28 am by Snout »

[stef2011]

the forum has got back online

[stef2011]

MD, PhD
Full Professor of Molecular Biology
Clinical Radiologist
University of Firenze, Italy

Department of Experimental Pathology and Oncology, University of Firenze,
Viale Morgagni 50, 50134 Firenze, Italy.

he is not a stupid doctor and considered a vey good researcher here in italy.

[StephenCastlecrag]

No-one says he is a stupid doctor, it is his view on HIV/AIDS. Watch the video. Yamamoto needs investigating.