1).. Is it normal for DnA and ALT to jump up and down so much with or without medication (or in-between as per my example).
yes because it is not avalable any test to measure hoost immune control on cronic hbv, plus it is like on antibiotics and you can get resistance and then......i am on entecavir and i am not even thinking of stopping tx, i would only 6 months after hbsab is developed and hbsag ultra und, and even in this case the virus is still in the liver for decades but immune system has complete control over it
2). Is an AFP of 1-2 (out of 10) quite normal... I was hoping it would be 0 but does 1 or 2 indicate theres a possiblity something is there?
there are many reasons for afp to be above normal especially on high alt flares.if you want to be 100% sure just check liver with ultrasound
3). Is Tenovif a good mono-tx? yes because it has no resistance up to now (3years) even if hbvdna is not und and this is very good.It can have some notable sides over time but it is too early to tell.i have choosen to start entecavir because no sides and only 1,2% resistance at 6 years but i will combo as soon as trials on combo are available, i am also planning to add alinia after first year as soon as some data on combo with nucs is available