Hepatitis B Interpretation

[Ingeniero]

Test Results:
Hepatitis A AB IgG
Result: Non Reactive   Reference Range: Non Reactive  
Hepatitis A AB IgM
Result: Non Reactive   Reference Range: Non Reactive  

Hepatitis B Surface AG
Result: Non Reactive   Reference Range: Non Reactive  
Hepatitis B Surface AB
Result: Reactive       Reference Range: Non Reactive  
Hepatitis B Core AB IgG  
Result: Reactive       Reference Range: Non Reactive  

Hepatitis C AB Screen
Result: Non Reactive   Reference Range: Non Reactive  

My question is:
What means the Hepatitis B Surface AB and Core AB IgG
Reactive result and the Reference Range Non Reactive?  
I need some Hepatitis B Interpretation.

[Hepatitis Researcher]

In HCV the remnant levels are probably much lower and sometimes nonexistent. Big debate right now as you know. Difference is, that the HBV virus at this stage is noninfectious, while HCV might still be infectious, because neutralizing antibodies are of very low efficacy.

To Jimmy - no at this stage even blood to blood transmission is noninfectious, since the HBV virus is coated with a layer of tightly bound antibodies that make it impossible for the virus to bind to its liver receptors.

[Hepatitis Researcher]

The fact is that in most acute recovered HBV cases there is virus to be found not only in the liver but also in the bloodstream, even a decade after acute disease. But this virus is not infectious, simply because it is complexed and neutralized by the surface antibody,it is circulating inside immuncomplexes. It is a combination of an efficient live long T cell response and a humoral neutralizing defense against the very small amount of virus that is indeed ongoingly replicating that prevents the spread of the virus and makes this person noninfectious.

[Jimmy1971]

When you say "makes this person noninfectious", does that mean you won't get infected even if you come in a contact with this person blood somehow in an intercourse? I know I am asking hard questions here. Thanks, Jim

[jboyhk]

I don't think you would know the definitive answer to this, but does the same hold true for HepC?

If one naturally clears the virus, is it possible that some small amount is still in the liver and the blood ready to be reactivated during an immunocompromised event?

Or is the fact that RNA is less stable than DNA that makes it unlikely to 'survive' the initial defeat of the immune system?

[jboyhk]

Thanks HR for correcting me. I stopped reading at the HsAB+.

Igno, as far as I know (and HR can correct me) at your status you are an extremely if not impossible risk to give HBV to somebody in normal everyday life.

[Ingeniero]

How I could get Infected with Hepatitis B?
What are their consecuence!?
Any cure available for my situation?
I'm worried about my child who's gonna born on May.

[jboyhk]

There is theory and reality.

Just like HIV is theoretical to get receiving oral sex, there are no known documented cases (that most agree with).

If its not in your blood/semen then it shouldn't be able to be passed along.

However, if you do have a regular partner, then why worry about these things when a vaccination is already available?

[Hepatitis Researcher]

Sorry, but this is not correct in this case. His anti core antibody is positive - this means sure exposure to the whole virus in the past, not vaccination.
With the extremely rare exception that he participated in one of the few HBV core vaccine trials, like we did a few years ago. Then the core AB would be pos as well, for vaccination reasons.

No, he got infected, seroconverted - acute or after some time- and now has both the surface and core antibody reactive. He also carries the virus in his liver - in small amounts - that would only reactivate once chemotherapy or intense antirheumatic therapy or transplantation is performed. Under these conditions a high percentage of previously exposed patients do reactivate and this can easily be prevented even with lamivudine - the Dr. just has to know these facts.

[Jimmy1971]

HR, you stated "He also carries the virus in his liver - in small amounts" does the virus exist in the bloodstream as well in this case (past exposure-resolved acute). Would you consider this person infectious when it comes to intercourse (sex)? Thanks, Jim

[Jimmy1971]

HR, you stated "He also carries the virus in his liver - in small amounts" does the virus exist in the bloodstream as well in this case (past exposure-resolved acute). Would you consider this person infectious when it comes to intercourse (sex)? Thanks, Jim

[jboyhk]

It means you are reactive to the antibodies which one would expect if you were vaccinated against the virus in the past.