Vitamin D and Prevention of Chronic Diseases

[melcul]

A very interesting presentation in which Michael Holick, MD,PHD, which comes with lots of examples,  discusses vitamin D deficiency ( from 2009 ). it is well known by now that vitamin D has effect on many diseases and cancers , i think that the only problem will be, how to be sure that a specific amount will not affect your kidneys.

http://www.youtube.com/watch?v=Cq1t9WqOD-0&feature=player_embedded

[stef2011]

sorry confusing sentences:
but again sick patients have mutated vdr receptors so all vit d in serum is not used in cells if vitd cannot attach vdr and get inside cells there is no absorbed calcium from whatever food

kinetics is a little complicated but it looks extremely clear to me, i stress again calcium can be absorbed and get in to serum, cells, tissues over normal range only if pth gets to undetectable for many weeks so checking pth, vitd and calcium in urine everything is in control a long time before any calcium increase can happen in serum

the thing to study now (i found only one study), what happens when we make pth extremely low pth at about 10pg/ml

inactive carries have low pth, low hbvdna, low hbsag, no /little liver damage and immune system is enhanced in low pth persons (any person) and suppressed in high pth persons

we, in this community, must reach a low pth and high vit d to see what happens to hbv.i dont think any study on this will be funded and we can t wait to see we better act

the effect on immune system is after 6 months of stable low pth and stable high vitd25oh

[stef2011]

Michael Holick, M.D. interview, a world expert on vit d and the scientist who discovered the tests to measure it

http://www.doctoryourself.com/holick.html

DY NEWS: Yet it seems to be particularly difficult to kill yourself with vitamin D.

HOLICK: True. One man took 1,000,000 IU of vitamin D per day, orally, for six months. Of course, he had the symptoms of severe vitamin D intoxication.

DY NEWS: But he lived to tell the tale?

HOLICK: Yes. His treatment was hydration (lots of water), and no more vitamin D or sunshine for a while. He’s perfectly happy and healthy. This was published in the New England Journal of Medicine. (Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med. 2001 Jul 5;345(1):66-7.)

DY NEWS: How many people have died from vitamin D or other vitamins?

HOLICK: I have no experience of anyone dying from vitamin exposure. In thirty years, I’ve never seen it.

DY NEWS: And in the medical literature?

HOLICK: Not as far as I know.

[stef2011]

this man took 186.000.000iu of vitamin d3 (1.000.000iu of vit d3 per day for 6 months) before having an increase of calcium from max normal range about 10.5-11 to about 15 with no consequences on kidneys

what we can get from this for sure is that vit d is absolutely safe

[stef2011]

the only words that can be used until now is, there can be possible increase of calcium with a healthy person and normal diet with diaries which are full of calcium when vitd25oh is over 150ng/ml

but again there can be because sick patients have mutated vdr receptors so vit d is not used and calcium is not absorbed from the diaries, so only possibilities here and single cases reposrted of no scientific value because reported cases not under a controlled study

the good is that even in this case:
1 milion iu of vit d3 per day made no damage, the person increased the water daily and stopped vit d and everything went back to normal

[stef2011]

my point in the post is vit d is different from healthy to sick patients and the word toxicity is wrong there exsist no toxicity and increase of calcium is not toxicity is just increase of calcium.

i already knew this case but it is not representative of calcium increase because the person was healthy, not sick

which is the real dose which makes calcium increase is yet to be found and in case of low calcium diet there is probably no dose that can increase the calcium because there is no calcium.calcium increase comes from the food and if there is no calcium in food it may not increase even with 1 billion iu

a serious study to find when vit d can increase calcium if there is no calcium in the diet is yet to be done.it is not vitd25oh level or the dose of vit d to make the calcium increase but the diet first of all and then the vdr mutated or not and the vit d dose

[melcul]

no, that was an example of Vit D toxicity . he end up in severe pains in the E.R.

[stef2011]

so in the end you have to check as i keep saying since months:
pth to be 10-20pg/ml
vitd25oh
calcium in urine
phosphorous in urine (not mandatory)
serum calcium
drink 2.5l of water per day
no dairies

[stef2011]

we are not going to take 1million per day.....it all depends on pth which is the correct dose because most of us have mutated vdr and of course no dairies

you know calcium cannot be absorbed if there is none in your gut to be absorbed and so cannot rise in the blood plus that example is comletely wrong for sick patients that was of an healthy person with normal vitd kinetics and normal vdr

i dont even check my vitd25oh anymore it can be from 1500 to 2000ng/ml by now but i only check my pth which will tell me when vit d is sufficent (when pth reaches 10-20pg/ml) and at last i found my vit d3 dose which is 150.000iu per day which makes my pth 16pg/ml.by no dairies diet my calcium is still low and in any case it may rise a little only if pth goes undetectable or less than 10

it is pth to regulate calcium absorption and responds to the vitamin d attached to the vdr receptor, so this is the best marker combined with vitd25oh to tell how calcium and vit d are moving in to receptors and cells

[melcul]

at 38:50 is an interesting example. accidentally a patient took 1 million  IU Vitamin D /Day (because the company from which he bought the supplement forgot to dilute it ) -> he had Ca=15.2 mg/dl , 25(oh)D = 520 ng/ml !