Aa
Is any treatmene needed? hbs+ hbe+ dna+
Hi everyone,
first of all I’d like to introduce myself to this community: I’m 23 years old, male – Italian (so sorry for my poor English)!!!
I’ve been having HBV since my birth (my mother is a Hbsag+ carrier) but I’m very healthy and I’ve never had digestion problem or anything else. I’m used to have a bier (0.4) during the weekend twice a month and I’m not a smoker nor a drinker.
Here is my current situation:
Hbsag + / Hbeag + / HBVDNA >100.000.000
These values never changed from my birth. Transaminasis have been always in the range ALT sometimes during the last 2 years reached up to 74 (range 0-55), AST and GGT have been always ok.
I had a liver biopsy in 2007. Everything was good, they found F1 (Metavir) but doctors said there’s nothing to be worried about. I had also ultrasound test once a year and no liver damages were detected.
I saw my doctors in May and they forewarned they would treat the disease despite the values are not so high. The suggestible drug should be Peg-IFN (up to now I do not know if in mono or combo mode).
I was pushing on antiviral treatment but they told I’m so young and I should not take drugs which I may continue to take for my whole life.
Why was I pushing on AV? I’m really scared about IFN side effects, I move every month out of Europe for job and I’m not sure I’ll manage to do it again if I’ll take it!
What do you think? Am I in the immune-tolerance or immune clearance stage?
Should I be treated? May I seroconvert the eAG without drugs, I read it may take up to 3-4 decades? Should I wait some years again and then evaluate what to do?
When you convert the eag form positive to negative do the VL be low for the rest of the life or it can also flare up again?
In case I went for IFN and it didn’t work, would I have another possibility of cure? I’m also scared about disease flares during treatment..
What about if the same happened with Antiviral?
Is there anyone who can share experiences with IFN side effect and job activity? Is there a relation between my age and such effect (may I easily tolerate them?)
As you see I’ve a lot of question which are running around in my mind… I’d be very pleased if somebody answers me or cans share his experience…
Ciao ciao from Italy
first of all I’d like to introduce myself to this community: I’m 23 years old, male – Italian (so sorry for my poor English)!!!
I’ve been having HBV since my birth (my mother is a Hbsag+ carrier) but I’m very healthy and I’ve never had digestion problem or anything else. I’m used to have a bier (0.4) during the weekend twice a month and I’m not a smoker nor a drinker.
Here is my current situation:
Hbsag + / Hbeag + / HBVDNA >100.000.000
These values never changed from my birth. Transaminasis have been always in the range ALT sometimes during the last 2 years reached up to 74 (range 0-55), AST and GGT have been always ok.
I had a liver biopsy in 2007. Everything was good, they found F1 (Metavir) but doctors said there’s nothing to be worried about. I had also ultrasound test once a year and no liver damages were detected.
I saw my doctors in May and they forewarned they would treat the disease despite the values are not so high. The suggestible drug should be Peg-IFN (up to now I do not know if in mono or combo mode).
I was pushing on antiviral treatment but they told I’m so young and I should not take drugs which I may continue to take for my whole life.
Why was I pushing on AV? I’m really scared about IFN side effects, I move every month out of Europe for job and I’m not sure I’ll manage to do it again if I’ll take it!
What do you think? Am I in the immune-tolerance or immune clearance stage?
Should I be treated? May I seroconvert the eAG without drugs, I read it may take up to 3-4 decades? Should I wait some years again and then evaluate what to do?
When you convert the eag form positive to negative do the VL be low for the rest of the life or it can also flare up again?
In case I went for IFN and it didn’t work, would I have another possibility of cure? I’m also scared about disease flares during treatment..
What about if the same happened with Antiviral?
Is there anyone who can share experiences with IFN side effect and job activity? Is there a relation between my age and such effect (may I easily tolerate them?)
As you see I’ve a lot of question which are running around in my mind… I’d be very pleased if somebody answers me or cans share his experience…
Ciao ciao from Italy
Now keep in mind, since you ask, this is my lay opinion.
No, I won't treat now if I were you. Especially if you don't want to do INF. For antiviral, you may need years and perhaps lifetime of treatment. And I have no experience with INF. I had experience with ADV mono, ADV and ETV combo, and currently on TDF and ETV combo now. I tolerated all antiviral treatment well. Don't feel any sides. I start treating at 31 with good evidence of the immunoclearance stage. And in reviewing my labs, this phase could have started 7-8 years ago. My doctor think I bordering close to the eSeroconversion, so it made sense to treat. But I am still eAntigen + and eAntibody - So it could take time. And knowing what I know how, I wouldn't have let my doctor started me on ADV mono. So if you do decide to treat, fight to get combo treatment. For more info on why combo, see this thread:
http://www.medhelp.org/posts/show/632664?personal_page_id=7068
No, I won't treat now if I were you. Especially if you don't want to do INF. For antiviral, you may need years and perhaps lifetime of treatment. And I have no experience with INF. I had experience with ADV mono, ADV and ETV combo, and currently on TDF and ETV combo now. I tolerated all antiviral treatment well. Don't feel any sides. I start treating at 31 with good evidence of the immunoclearance stage. And in reviewing my labs, this phase could have started 7-8 years ago. My doctor think I bordering close to the eSeroconversion, so it made sense to treat. But I am still eAntigen + and eAntibody - So it could take time. And knowing what I know how, I wouldn't have let my doctor started me on ADV mono. So if you do decide to treat, fight to get combo treatment. For more info on why combo, see this thread:
http://www.medhelp.org/posts/show/632664?personal_page_id=7068
hi all.. had a phone chat this afternoon with dr...she was still pushing me on IFN or just monitoring for other 5/6 years... she did not suggest me AV (etv and tfv) at this stage.. I'm pretty young and I may develop resistance to them if i stay on AV for a long time...this is her opinion.
she stated that I may also naturally seroconvert (anti hbeag +) without any drugs..
She explained me also thath it's very difficuly to stop AV and to do it you have to shift to IFN for a few time before stopoing those drugs... what do you think about this statement?...
Steven.. please share with me your experince on ETV.. what about you eag status? how is it currently?
many thanks in advance to you all
she stated that I may also naturally seroconvert (anti hbeag +) without any drugs..
She explained me also thath it's very difficuly to stop AV and to do it you have to shift to IFN for a few time before stopoing those drugs... what do you think about this statement?...
Steven.. please share with me your experince on ETV.. what about you eag status? how is it currently?
many thanks in advance to you all
would you treat righ now?
I'm a bit worried about the fatc that they'd put me on a trial combo tx etv+tfv.. and if I developed resistance (this may be likely due to my high hbvdna...right?) I would no longer go for this kind of antivirals for the rest of my life...In any case I'd prefer to avoid ifn.. do you have any experience on it??? especially about sx? are you still on av? thx in advance your help is highly appreciated
I'm a bit worried about the fatc that they'd put me on a trial combo tx etv+tfv.. and if I developed resistance (this may be likely due to my high hbvdna...right?) I would no longer go for this kind of antivirals for the rest of my life...In any case I'd prefer to avoid ifn.. do you have any experience on it??? especially about sx? are you still on av? thx in advance your help is highly appreciated
I answered your other post earlier:
It the traditional sense, yes, you start off as eAg positive. It's the wild-type (kind of like, the virus left alone in the wild to do its thing) strain that releases the eAntigen on viral replication. And if you infected with the wild-type, then it usually takes its course, and for some they get the mutation (PC, BCP) at seroconversion.
It looks at your immune system is starting to recongize the virus and is in very early immuno-clearance phase. This could take years and you could stay eAntigen + for years with high DNA, which puts you at a higher risk for developing antiviral resistance. It's very important to drop the DNA quickly if you decide to treat.
So my thought is still the same. I would treat either with combo, TDF and ETV. Or INF to reach a low DNA, then mono with TDF or ETV. The goal is to lower DNA to UND as quickly as possible to minimize risk to antiviral resistance. By doing this, you may speed up the seroconversion process (hopefully). So talk to your doctor...good luck. And come back and keep us informed.
It the traditional sense, yes, you start off as eAg positive. It's the wild-type (kind of like, the virus left alone in the wild to do its thing) strain that releases the eAntigen on viral replication. And if you infected with the wild-type, then it usually takes its course, and for some they get the mutation (PC, BCP) at seroconversion.
It looks at your immune system is starting to recongize the virus and is in very early immuno-clearance phase. This could take years and you could stay eAntigen + for years with high DNA, which puts you at a higher risk for developing antiviral resistance. It's very important to drop the DNA quickly if you decide to treat.
So my thought is still the same. I would treat either with combo, TDF and ETV. Or INF to reach a low DNA, then mono with TDF or ETV. The goal is to lower DNA to UND as quickly as possible to minimize risk to antiviral resistance. By doing this, you may speed up the seroconversion process (hopefully). So talk to your doctor...good luck. And come back and keep us informed.
.. my last "in range" ALT was detectec in September 2007 - 45 (0-55) and from thah date it' soncitnously increasing... I've been monitoring it evry months.this is the trend..
45 - 59 -62- 64- 68- 69- 71- 72- 73-84.... immunoclearance????
45 - 59 -62- 64- 68- 69- 71- 72- 73-84.... immunoclearance????
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