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Is it safe to be on etv+tdf combo even after hbv dna getting undetectable?

Is it safe to be on combo even after DNA getting und.(patient is lam resist).
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Patient is both lam & etv resistant & is on etv+tdf combo for the last 10 months.
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yes its safe although tdf works perfectly also mono on lam resistance
Actually the patient is feeling very weak...but doc is insisting on continuing with the combo for another 4 months despite dna being -ve.The sgpt is 45 and sgot is 50 which he considers to be slightly elevated....
Steff,can you tell me if there can be any side-effect arising due to tdf?especially w.r.t thyroid.....my mom has become weak and is suffering from some amount of hair loss also.She has been taking a lot of supplements like iron,folic acid,multivitamins,Cal 500+Vit d3 2000iu but for the last few days she has become very weak.... If possible please suggest some tests regarding thyroid....
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