Struggling with HBV for the past 5 years now, i can definitely let you know that : Watery diarrhea, Lack of appetite, Erectile dysfunction, Tiredness, lack of interest are all symptoms i've experienced while being constantly depressed and stressing out. So It's definitely not only from your meds or Hbv. The mental state is very important in this. Like you, i was spending lots of time inside and couldn't think of anything else but this. Of course, your blood tests will give you all the answers, but have this in mind
It can be from the drug itself. But also the virus has his effects. From what I have read on different research papers, the antiviral has a level of toxicity over the way mitochondria works (the power plant of our cells). By affecting the ATP process. All this can cause neurological symptoms plus other symptoms: fatigue, peripheral neuropathy, central nervous symptoms and so on. You can search on internet to see what supplements are good to support mitochondrial function.
Also you can read more on this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449/
It will be good if you check your B vitamins levels: like folic acid, B12 vitamin maybe other elements like zinc, selenium
But fore sure is good to check with a Doctor. Because supplements not taken correctly can promote more harm than you imagine.
So all of this is still happening, though my sleeping is getting worse. At times, I may be able to sleep 7 hours but my sleep patterns are very different and I've been asleep much earlier than normal and awake throughout the night with the inability to get back to sleep comfortably. I do not feel rested at all, not like I was before, where I was sleeping a lot and even middle of day I'd feel tired enough to take a quick nap. I'm not getting this now. I'm concerned that I am not responding to my medication still, even though I've taken EVERY dose, so I made an appointment with the doctor to discuss... though because he is out of town, I have to wait a week now. I just wanted to follow up on this because I still don't have any idea what to do. I'd like to get a good night's rest, and maybe I am thinking about this and other health issues and work too much, but I am unable to feel like I got a good night's sleep. I hope this changes soon. The only thing I've done differently since this all started, was start to see a chiropractor for my neck and back issues. I'm hoping there is not some adverse effect here that causes me to get a resistance to meds from the work they do.
So good news, I got in with a doctor earlier today and they drew some blood tests (Unfortunately not HBV Viral Load but all the other tests) to see where I'm at. No ultrasound ordered. They said that if my Liver Function Tests are elevated, then they'll do more tests for Viral Load, but if not then they will stick to the plan on the trial. What I was told:
1. This could be Hepatitis A - since there was an outbreak in our area - but likely not since I was vaccinated against it.
2. It could be a bacterial infection (they took a stool sample from me, thankfully that went easy even if it was anally). If so, it may just be a course of antibiotics to fix it
3. While doubtful, if my Liver Enzymes are elevated, then they'll check viral load as it could be a resistance to TAF.
These were really the 3 main concerns. Granted, the doctors were concerned with the extra weight loss too. But they shrugged it off as "Extra weight loss may occur with a lot of diarrhea, so it could be that." My concern of course is some form of cancer. They did do a full work up, including white blood cells, kidney functions, liver functions, electrolytes, etc. I could not choose what I wanted as they took what they called a safety measure test. The good news is, I have no phone calls back the same day with any alarming info, so hopefully nothing serious and I should know results come Monday/Tuesday the latest. In the meantime, I have opted to go against adjusting my back any more. I feel this could have triggered something (neck is a different story, I may have to continue this or it may require surgery) through all the chiropractic work since this is when it started. So I will see how that plays out in these next 2 weeks. I told them everything I had was the same experience prior to medicine, this also included muscle wasting. I was fortunate enough to get in as quick as I did, I'll keep you guys updated on any condition.
Update here, I got my blood tests back and everything on there was within normal range EXCEPT the Creatinine and Glucose. Glucose was fairly high. Here is what they measured:
WBC - 7.9
RBC - 5.20
Hemoglobin - 15.8
MCV - 89
MCH - 30.4
MCHC - 34.1
RDW - 12.8
Platelets - 298
Neutrophils - 69%
Neutrophils (Absolute) - 5.5
Lymphs - 23%
Lymphs (Absolute) -1.8
Monocytes - 6%
Eos - 1%
Eos (Absolute) - 0.1%
Basos - 1%
Basos (Absolute) - 0.1
Glucose - 122 mg/dL
BUN - 18 mg/dL
Creatinine - 1.30 mg/dL
eGFR - 67 ml/min/1.73
BUN/Creatinine Ration - 14
Sodium - 140 mmol/L
Pottasium - 3.8 mmol/L
Chloride - 100 mmol/L
Carbon Dioxide Total - 21 mmol/L
Calcium - 10.0 mg/dL
Protein (Total) - 7.3 g/dL
Albumin - 5.0 g/dL
Globulin, Total - 2.3 g/dL
Alkaline Phosphate - 64 IU/L
AST (SGOT) - 22 IU/L
ALT (SGPT) - 34 IU/L
They did not measure HBV DNA. They said they would only do this *if* my liver enzymes shot up for some reason, but my AST did go down a bit here. I'm still waiting on results from the stool sample as well.
Update here, stool samples all came back clean as well. Nothing detected and they checked for all these viruses and infections in the stool (E.coli, c.diff, Norovirus, etc.) I'm at a loss as to what has caused this.
So all these symptoms are still happening, and no answers. I'm seeing the doctor on Monday admist all the crazy Coronavirus stuff going on. However, I think I am on to something:
I need to get this monitored ASAP, because it's possible that after taking 10,000iu all these years and being outside as much as I have (even if it was winter, I may be getting Vitamin D3 from sun), that I reached a level that was too high. I am experiencing a few of these symptoms, as noted in this post, and while my Calcium Levels were normal, my Vitamin D3 levels may have reached too high. A lot of this continues on daily and I noticed it was worse during the day after I take my D3. Usually by evening, I'm feeling better, but lack of appetite, weight loss, diarrhea, elevated kidney function and yes even some bone loss in my jaw (I can feel it) along with muscle wasting in my legs. Most of these are reported on this article. I know it's easy to say "10,000iu a day won't cause this" but after years of consumption like this, it may be one of the leading cause of my symptoms. Either that or I am experiencing liver failure, but I would think that would only come with an extremely damaged liver from tests and my last tests 3 months ago did not see this. I'll keep you guys posted on here!
My doctor did say that 10,000iu daily of D3 for many years was a lot. I totally forgot to ask him about Vitamin A and Magnesium testing. Whatever has been occurring, seems to be subsiding over time and only think I've done differently was not take Vitamin D3 for a bit of time over the course of a few days.
Update here, since it's been about 2 1/2 weeks since my last one. I'm not longer feeling sick short of a slight cough since the last update (It probably started on the 16th). Appetite is back, in full force, and I have not had daily watery Watery diarrhea. No extra weight loss, though it's been slow to gain some of it back. Some of the weakness I'm experiencing may be due to my neck issues but the other I was experiencing, I can tell a difference and feel stronger again. I'm not neausous or depressed and my sleep cycles are no longer really disturbed. I feel well rested when waking up, for the most part. I'm strongly convinced that I had or have COVID-19 and my body is finishing up clearing it out. I read an article that digestive issues, which may include diarrhea, are common problems with people dealing with COVID-19. Unfortunately, doctors didn't test for this and also unfortunately, they did not diagnose me with anything else (though maybe that is fortunately as well!) I'm still waiting for results from my hbsag and Vitamin D panels.