My profile and Results

[mike9111]

I'm an HBV carrier since birth like most of the members and I did lot of tests in the past year. My hepatalogist is one of the world leading in HBV professor Anna Lok. My results are fluctuating and I'm on no treatment and never been on treatment. I tried to put as much info on supplements I took and duration as well with the time frame.

2007
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HBV DNA 16120 IU/ML
LIVER BIOPSY  Read negative for Fibrosis

2009
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HBV DNA   160 IU/ML
ALT/AST Within Range

2010
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HBV DNA 13220 IU/ML
ALT/AST Within Range

2011
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HBV DNA   2670 IU/ML
ALT/AST Within Range
Ultrasound  Coarsened Liver

June 2014
---------------
AST  18
ALT   20
HBV DNA 1118 IU/ML
FIBROSCAN    7.6 KPA
Ultrasound  Subtle Coarsened Liver

August 2014 (Test done in Germany)
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AST   25
ALT    39
HBV DNA   38200 IU/ML
HBSAG QUANTITATIVE    223 IU/ML
GENOTYPE   D
Vitamin D   32 ng
Started vitamin D 6000 iu

September 2014
-----------------------
AST    36
ALT     55
HBV DNA   9472 IU/ML

December 2014
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AST   19
ALT    21
HBV DNA   303 IU/ML (Very low)
Started black Seed every morning with food
Pure Honey one spoon on empty stomach in morning

March  2015
------------------
AST   26
ALT   36
Vitamin D  23 ng
HBV DNA   4608 IU/ML
FIBROSCAN   4.7 KPA (Much lower than previous read from june)

My professor before fibroscan was thinking of trying interfron for a year after i kept asking and she said if fibroscan show worsen than my last reading but it came way below that. She did say few things that align with what Stef and others been saying. I asked her if i should go nuc first to get undetectable DNA before interfron and she said in my case interfron mono would be ok since my hbv dna is not elevated. Also she said that precore mutant will not increase the risk of hcc but the genotype C and basal core are the one that at increase. In all means she said in the next 10 years my risk is low but after that she can't predict. One last thing she also commented on future and she said most hepitits C researchers have to work on HBV or otherwise they will go out of business since HCV is cured.

[Quincyw33]

When I look at your history it is very clear that when you started taking vitamin D your HBV DNA dropped dramatically.  It seems like everything is the result of vitamin D. If you pay close attention you will see that your HBV DNA went up whenever your vitamin D level went down. Congrats. Keep the vitamin D going.

[mike9111]

Here is my latest Results:

September 2016
----------------------
AST 22
ALT 21
Vit D  23 ng
HBV DNA   336 iu/ml
HBSAG Quant. 79 iu/ml

Fibroscan = 5.5 kpa

Ultrasound Result: Coarsened hepatic echotexture suggesting chronic hepatocellular disease, possibly steatosis. No morphologic findings to suggest cirrhosis. No suspicious focal hepatic lesions.


My ultrasound was always reported as "minimal corsened" on this one they didn't say "minimal" does that mean it progressed?

[stef2011]

ultra sound is good only to see fatty tissue, liver size and nodules mainly so i would not worry much about coarsened word but i d worry a lot about steatosis work

[stef2011]

worry a lot about steatosis word

[stef2011]

you need to increase your vit d levels, vit d is mandatory for control of metabolic diseases especially when we are not very young, so i d make vitd25oh at least 80-90ng/ml and see what happens at next ultrasound.i dont think hbv has anything to do with this

[mike9111]

So he said possibly steatosis is he suggesting faty liver? If fat does it mean fibrosis or not neccessary?

[mike9111]

For those who are following me with my HBV journey I appologize for not posting much lately as life getting very busy. Here some interesting things that happened since my last profile post to help maybe someone with analysis and research:

1) Continually doing HBV DNA with the latest result in june (fluctuate between 2000 and 300 iu/ml)
2) Ultrasound still same result as every year "mild heterogeneous liver"
3) The interesting of all is the HBSAG quantitative which came back at 3.80 iu/ml

Not sure but I will be meeting my professor Lok next week to know more with Fibroscan. But her comment on my portal was very encouraging as she said "very low level. This is great". Does that mean I'm clearing?

[Aduiski]

it is 1700 iu/ml

[mike9111]

What is your hbsag quantity Aduisky? I'm like you genotype D

[Aduiski]

Thx Stef

[stef2011]

i d be very interested on cuban vaccine too as an add on and if cheap in cuba

[stef2011]

i just replied privately but better put it public too so we help others in similar situation

we have see gcmaf and vit d3 can prevent heavy sides from peg, only few members tried this but i think it worths to try this add on to peg.if sides are not heavy suggestion from top researchers is not good because with your low hbsag and genotype d it worths try 12-24 weeks to see response and if no response then go for tdf
if we go to tdf directly we dont know if peg can give an immune boost that may last for 5-10years making a faster hbsag decline on tdf mono

[Aduiski]

I am geno D...so I decided to either start with tdf or entecavir with a most likely switch to taf when it becomes available in australia (2-3 years from now..at that time we'll also have more data on its long-term effectiveness).

I just recently contacted few top-notch research doctors...they are advising me to get on NUCs rather then interferon and wait for upcoming newer medications for hep B.

What is your opinion?

[stef2011]

tdf or peg?

[mike9111]

I expect my next test in 2 month to be decreased because it fluctuate

[Aduiski]

you never know...its an unpredictable disease...
I think getting on treatment would not be a bad idea...since many people enter immune escape phase at around or shortly after 40....

[Bm2016]

I wanted add more info about my previous lab result
the subsequence lab results after May 17th, 2015
, which are in July and December 2015,  hep B DNA quant PCR result, HBV DNA NOT DETECTED.

[Bm2016]

Jan 30 2015 , hbv dna virus  detected 1860iu/ml

May 17th 2015, hbv quant pcr dna not detected

July 25th 2015, alt 52, ast 30
Hep B surf Ag nonreactive
Hep B surf Ab reactive

December 26th, 2015, alt 47, ast 23
Hep b surf Ag nonreactive
Hep b surf Ab reactive

[StephenCastlecrag]

Thank you for your post. HBV has many mysteries, virological breakthrough(increase in hbvdna) during antiviral treatment is one of them. Why?What is the mechanism? Sometimes virological breakthroughs can be attributed to non-compliance, but some seem to have no explanation.
Can I clarify, you have developed HBsAb but you are still HBsAg positive?

[Bm2016]

my hbv dna went undetected for a few years, (maybe since 2009 or 2010),  and I've been taking viread daily. Last January, blood work shown sudden spike in hbv dna, and dr also asked me to do another blood work in 2 months as well, I was trying to blame the delicious New York steak once from Costco I ate a week before the bloodwork, then in May 2015, HBV dna went undetected again, and July 2015 bloodwork, HBV surf anti-body developed.  It is possible the immune system need some stimulation rom hbv dna to make hbv surf anti-body.

[mike9111]

After losing control i assume they started you on treatment? Or were you on treatment from the begining?

[Aduiski]

I'll start the treatment in few days...

[mike9111]

I just don't get the difference in fluctuating 2 to 3 logs

[Aduiski]

I was fluctuating like that too...untill started loosing control of my virus...

[mike9111]

Ya that is why i went to my general physiscians in june for ultrasound :)

[mike9111]

I just completed another set of testing and doesn't look good. Seems viral load is at highest as seen.
March 07 2016
--------------
AST   23
ALT    40
Vitamin D    21 ng
Hbv DNA     26773 iu/ml
The Professor asked me to repeat in 2 months and if still elevated then she will put me on treatment.

[Aduiski]

well...you'll see what will happen in 2 months mike...

[sorte]

You professor is statistically right, but ultrasound is not so expesive so I think you should make tests anyway every 6 months, better react early than regret.
Notice that all recomendations is the consensus between medical knowledge and money to spent by healthcare :)

[flyinsky]

I have This 2conditions but m'y hepato didn't put me under nucs because she sees that I have 0fibrosis so no damage.i think treatment of hbv defer from doc to another and from patient to another .i will see her next month and see what will suggest according to my blood test and us.i did biopsy and fibroscan on April if I remember well.

[mike9111]

Ya my professor think no medication at all. Even ultrasound every 2 years. She say im young and when i ask her about the articles and guidelines. She say most of these statistics are made for asians and who didnt get monitored and no drugs were avaialble then. She said im under monitoring and once she see a rise in my hbv dna > 20000 iu or a raise in Alt she will use antiviral or peg

[flyinsky]

Ut is true m'y hepato wants to put me under interf but she hesitates because of sides effects on me and on my children so no problems with insurance.but my next check I will discuss well with her about this I want really to give my body a chance.

[stef2011]

it kind of follows drug makers/insurance companies power over governments...US and UK too lately almost run by these entities on helathcare field

[sorte]

I think it's US specific that doctors or maybe rather insurance companies don't like interferon. In Europe it's usually first line drug if no contraindications. But that depends on the country too, in UK they prefer nucs too.

[twinboys1girl4me]

I can relate Mike.  Although I really like my Hepatologist, a have lost faith in all specialists in my State wanting to cure HBV.  Yes, they want to treat with antivirals but when asked about add on Interferon down the road none are fans.  Is this what you are referring to?