Need your help! I am very appreciated!!

[secrect_garden]

Dear all friends in forum!
I am very heart breaking when I learned that my beloved mum got cirrhosis. She sufffered from hepatis B.She used nucs for more 5 years but the situation get worse day after day. She is 55 year old now. First two years, she use lamivudine then afer her doctor change to bacraclude ( entacavir) . in a year Hbv dna become undectable but recently check, it started rise
Her alt. ast away fluctuate from 40 -50. fibroscan more  24
I ask her doctor to change to tenofovir but she refuse, she say it's not necessary.She just prescribe entacavir  for 3 month and other supplement dietary. I am very confused
How can I do to ease my mum's pain? or at least keep her situation stable.
A lot of people get hepatis B but my mum seems  heavily than any one.
She also suffer LACKING OF SLEEPING, ONE DAY SHE JUST SLEEP 3-4 HOURS
CAN YOU HELP ME. SORRY MY ENGLISH IS NOT GOOD

[melcul]

if she developed resistence to other antivirals such as lamivudine, her risk of developing to other antivirals rised, see what steff write above

[secrect_garden]

Sorry my mum do not have fat liver. She weighs 58 kilos and 1.58 metre height. I think her liver get cirrihosis bcause hep B. I want to ask you what the factor or what test could reveal whether her livers decompensated or compensated.
Her doctor also give her suppliment dietary but it seems not much help.
I will follow to advice, I had bought for her melatonin, hope it will works
Thank u so much.

[secrect_garden]

Yes. she develop resisitance, the lastest test which did two week showed that hbv dna still detectable, she had use Entacavir for 2 years, I really don't know why ? I remember read a survey show that only 1% hep b develop resistance after 2 year using entacavir. May be she belongs to that 1%.However entacavir is the strongest nucs now

[stef2011]

melatonin helps with sleep and is a good antioxidant, no sides

[stef2011]

you can blame the doctor for her situation lamivudine can t be used on hbv and is proposed for a ban, entecavir can  t also be used once lamivudine is used because they share same development of resistance and then entecavir resistance is difficult to manage, change butcher immediately a doctor like that can only work as a butcher and get your mother tenofovir plus entecavir, resistance to a nuc can be deadly for her so the combo must be used here

i hope you dont have financial limits because all the regimen to keep cirrhosis stable or reverse it is expensice.i had compensated advanced cirrhosis with fibroscan 16.2kpa and got fbroscan about 6kpa in 1.5years, if she is not compensated i dont know if regression can be so fast, anyway this is what i did:

- diet and supplements to lower weight and solve fatty liver too, i will link the diet
- tenofovir plus entecavir
- gcmaf (old gcmaf at that time, also goleic gcmaf is available now which is more potent)
- heptech supplements

diet
http://www.medhelp.org/posts/Hepatitis-B/update-on-my-fatty-liver/show/1500346

BMI must be less than 25 and weight low normal for cirrhosis to regress, also no fatty liver

[melcul]

from my point of view, it is possible that she became resistant to lamivudine(also known drug for creating mutations) i belive that being in her 50's the doctor chose lamivudine for her, and after became resistant changed the meds to entecavir, the smart thing to do was to go with tenofovir after lamivudine resistance . so now after she took entecavir, hbvdna start rising again ?