Normal vit D levels are associated with hbsag seroclearance.

[Rome70]

Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.

[stef2011]

no it is not enough at all for us, it is low.you also have to check intact pth because most of us have receptor resistance and vitd25oh doesn t tell us the level of vit d
pth lowest value of normal range means there is enough vitamin d

[pong58]

Is vit25OH of 45.8 ng/ml enough? I'm taking 4000 iu of d3 daily

[stef2011]

Your vitd25oh 124ng/ml looks the most effective on hbvdna, get vitd25oh to 150ng/ml and pth 10pg/ml and lets see if the trend of hbsag keeps the decline

of course nodiaries,2.5l of water and calcium in urine 24hrs test every 3 months

[mike9111]

If you can convince your doctor to give you PegInterfron then you might have a chance to clear since your HBSAG is <1000 iu/ml

[yibok]

Hi Stef
Below is my latest test reports

Date             HBSAG       HBV DNA   Anti HEV Ig M     Vit D25OH
17-Feb-14         944         3190                Not done                  16
22-Apr-14          831         364                 10.71                       124
26-Sept -14        674        1080                  1.80                       83

Hbsag is in IU/ML ( Quantitative ) and HBV DNA also in IU/ML & D25 in ng/ml

Now Iam only on Vit D 20000 IU . No other medicnes from last six month.

Will Hbsag levels go further down from here on .

Thanks

[stef2011]

it is not the dose but keeping vitd25oh between 100-150ng/ml, for her 10.000-15.000iu daily are enough to reach this.
i need 20.000iu daily for example just to keep the levels and loading dose of 50.000iu daily to reach 150ng/ml
lately i lowered to 10.000iu daily thinking it would keep the levels, in few months vitd25oh got back to 90ng/ml...

so you have to find your dose to get to high levels and monitor pth too, to see if vit d is biologically active.both me and my sister have vit d interference and resistance since pth does not get to low levels despite such high values of vitd25oh
when vit d is very high pth must go to very low normal range if the vit in your blood is biologically active, some must care to keep low norm levels but not undetectable.low norm range pth is healthy but undetectable is not good