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Avatar universal

REP 9AC and Replicor

I have some feelings that Replicor might have ditch development of REP 9AC as so much has been said about it and nothing has happened in terms of making this magic cure HBV claimed drug available to patient. Is it to do with greedy as always by corporate organization? Surely someone should think of good name and history that comes with it. Lets write to Bill and Belinda gate foundation to speak to CEO of Replicor if this will help for guys in the USA.

65 Responses
Avatar universal
Great idea!

You are right we as HBV world wide united have to stand up for this historic drug  if indeed this drug works so it reaches everybody in need.

But first we need somebody from  Replicor to come here and really say it that they need help to raise funds for them.

It is very easily done on these HBV forums. Because we can all go to forums in our countries and spread the word. And on their servers they can set up PayPal donations easily too.

Also it is possible to raise funds simultaneous through private investors if more of us with friends in the business world were a walking cure proof.

Raising funds is easily done today if the company such as Replicor wants to.

Funds can be raised even without Bill Gates.. there is 300 million HBV sick people world wide, if 100 million only donate a dollar then there you have it. We can also raise funds for clinics that will be giving out this medication if needed. And it does not have to be in the West if  the current laws are somehow against it.

So I think we first need to write to Replicor CEO, Michel Bazinet and ask her to come here and discuss their situation.

We will support them and any other honest company and doctors that are on the side of the patient and want to really help. And we will make sure that they will make all the money to pay for their time and investment.

If they will collect donations online they will get more then the big pharma will ever offer them.

So the plan should be going to the people and reaching out and we will pay for the meds, even for those that cannot afford them.

So I propose lets all email Replicor folks with the link to this topic and ask them to join us here. So we can together and work out a plan to make this cure come a reality as soon as possible.

And people we have to be committed with this and start writing to these companies.. here are the Replicor contacts

Michel Bazinet, MD
Chairman of the Board & CEO
***@****


Andrew Vaillant, Ph.D.
Chief Scientific Officer & Director of Operations
***@****

Also after you send your e-mail post here below your support so we can show how many of us are standing united. And how many of us want a cure today! Not in 4-5 or 10 years!

If you have your own personal struggle story, with the fight against HBV, post here and a little about yourself too.
Avatar universal
Michel Bazinet, MD
Chairman of the Board & CEO
mbazinetaATreplicor dotcom

Andrew Vaillant, Ph.D.
Chief Scientific Officer & Director of Operations
availlantATreplicor dotcom
Avatar universal
I wrote to replicor recently, and they said it is still 3-4 years to go...
Avatar universal
Did they share results about their study that was completed in Bangladesh?
Avatar universal
I did not ask, actually did not know about the study, but I think if it is not disclosed to public they will not tell anybody. There is so little info about the drug on their web, probably it is not as good as we expect, otherwise I see no reason why they do not inform public about the progress of the drug approval.
Avatar universal
This is not correct. Replicor has presented papers about their clinical trial results at international conferences, the most recent one was at ISVLD in Shanghai in June. In November they will present at the AASLD Conference in America. See their website under news.
Avatar universal
Did anyone attend ISVHLD 2012)?
Seem there was update from Replicor..

REPLICor to disclose interim REP 9AC / 9AC’ clinical efficacy data in patients with chronic hepatitis B at the 14th International Symposium of Viral Hepatitis and Liver Disease (ISVHLD 2012)
Avatar universal
Sorry Stephen, where can we see those results?
Can you send a link?
Avatar universal
Replicor folks and others need to come over to these forums and participate rather then reveal their progress on industry  trade shows whos sole purpose is to generate company exposure and investments.

You see. To us it may be a cure. A chance at the normal life. To these companies it is an opportunity to market their products.

That is why when you write to these companies ask them why they dont come to these forums and participate. And  answer questions. Why wont they recruit patients from these boards and do mass studies directly with patients. And we share the results here live and get instant feedback from 300 million  infected folks. That will fund their time and efforts far better then the few private investors.

Cure from HBV; HIV  and cancer cannot be a product dependent on the venture capital of few rich individuals or  one corporation. These are global crisis issues that require global participation.
Avatar universal
This is the abstract from last year's AASLD. Later results had been posted here before, you will have to do a search here. The proceedings from the ISVLD 2012 were to be published in the Journal of Viral Hepatitis, but they have yet to appear. The AASLD 2012 abstracts will be available in November.

AASLD 2011
REP 9AC / REP 9AC’: Potent HBsAg release inhibitors that can rapidly elicit durable immunological control of infection in patients with chronic hepatitis B
Mamun-Al-Mahtab1, Michel Bazinet2 and Andrew Vaillant2
1Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
2REPLICor Inc., Montreal, Canada
BACKGROUND: HBsAg suppresses host immunity and permits chronicity of HBV infection. REP9AC / REP9AC’ are nucleic acid-based polymers (NAPs) that block HBsAg release from infected hepatocytes. The current clinical results with REP9AC and a 4th generation NAP (REP9AC’) are disclosed.
METHODS: Patients with pre-treatment HBV DNA titers between 106 and 1012 copies/ml were treated by IV infusion. Virologic response was assessed using the Cobas and Architect testing platforms.
RESULTS (REP9AC): > 99.5% reduction of HBsAg occurred in seven of eight patients within 7 days to 32 weeks of treatment. All responders achieved 3 - 7 log reductions in HBV DNA. Four responders achieved complete control of their infection with 20-44 weeks of treatment (HBV DNA < 500cpm). Off treatment, three patients had sustained immunological control of their infection (HBV DNA < 500cpm, and HBsAg  90% reductions in HBsAg and 2-7 log reductions in HBV DNA). Mild pro-inflammatory side-effects accompanied drug administration.
RESULTS (REP9AC’): REP9AC’ is more stable with reduced pro-inflammatory activity compared to REP9AC. Interim data show robust HBsAg reductions in all seven patients in the first 10 weeks of treatment. Three patients have already experienced a 3-4 log decline in HBV DNA. Pro-inflammatory side-effects during administration were substantially reduced.
CONCLUSIONS: NAPs can affect rapid clearance of HBsAg, allowing restoration of host immunity. These results suggest that NAPs may become an important new tool in the treatment of chronic hepatitis B.
Avatar universal
REPLICor is a private Canadian company based in Montreal. Most of our shareholders are private individuals and companies that share our vision of creating a drug that has the potential to revolutionize the treatment of patients with chronic hepatitis.

You see they say they are a private company with shareholders. That is the problem of today people. Private companies are in charge of cures for hepatitis hiv and cancers. And must generate profits for their investors.

These projects should be funded by governments period. HBV threat kills more people per year then any terrorist organization. And yet cures for HBV are done by private investor operated companies.

Do you find this making sense?  300 million sick people world wide facing liver cancer and early death and they are doing clinical trials every few years on only 30 people? And this has become a standard procedure these days. The so called FDA approved.

So this is the issue guys as to why it is how it is. Because we the people are silent  about  this. We want a cure but are not willing to stand together for a common cause.

And these companies and their researchers dont even care to come here and explain  their position to the people they say they are so eagerly are trying to help. Human factor is gone from the society today in general and replaced by the stride for money. Which lead to the total degradation of societies and medical ethics.  
Avatar universal
Thanks for sharing this info. Results are very good.

Which brings again the need for an internationally funded hbv combat team of researchers.  It would be very interesting to see how would Rep 9AC works with Tenofovir; Baraclude and interferon. Or with imiquimod. That is what needed big steps forward.
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