I dont understand what else they have to prove.FDA has to grant accelerated approval to this drug and not pushing people on lifetime drugs. At least give this on compassinate basis to people who suffer the most, liver cancer patients, cirrhosis patients who do not have other alternatives. But once again big pharma wins and we can do nothing to change that. What a pity...
Interesting and most promising so far..
Well done Replicor
is there a poster about this?
i am not confortable with some words used because a little generic.this treatment is wonderful but we need to understand how our immune system control cccdna in the liver cells fter hbsag is negative and hbsab is high, this is important because a relapse at this stage can be connected with an hbsag mutation
so to sum up:
rep9ac in combo with peg and zadaxin:
12weeks combo all develop hbsab, hbsag und and what about hbvdna values?
8 control infection even after all therapies are stopped, does this mean hbvdna und?
what i am unsure of is:
hbsg is cleared by blocking the release of the particles and hbsab becomes detactable but what about cccdna in the liver cells?
was that cleared by peg?was that cleared by our immune system when hbsag und?or it is all there in balance with hbsab......
time will tell if hbvdna by high sensibility pcr is less than 10iu/ml after 48weeks i think the infection should be well controlled and definitely over or maybe a biopsy to check cccdna in the patients so we know 100% the infection was cleared
in any case this is the fastest drug we have to clear hbsag and a long period with tdf would be able to ensure there are no relapses whatsoever after we clear hbsag and develop hbsab
will this ever get to clinically available for more patients?
You often said that HBDNA is nothing so in this case they didn't mention it.
I can get more info from the guys if needed..
Replicor website states "Profound increases in anti-HBV antibodies or immune function were observed in all patients with as few as 6-10 weeks of combination treatment."
My understanding is that increase in anti HBV antibodies or immune function 24 months after treatment is enough to proof that the treatment is working.
One more important point to mention, I am not a Replicor agent, so people feel free to direct your questions to the company.
this is a repost of the full replicor abstract that was posted a few days ago. You can find it on medhelp website
in this case hbvdna is important to understand if cccdna inside liver cells is still active.
the difference with the other treatments is cccdna is slowly decreased so that hbsag decreeases, with replicor it is different hbsag decreases because secretion is blocked but we dont know about cccdna so remaining hbvdna at very low titers might reflect cccdna is still there
in any case making hbsag und in the blood activates our immune system so even if we have cccdna in the liver cells the immune system should be able to take care of that.
i guess studyforhope is the only one here with enough knowledge to know what happens
all this is great!
When can we try it? That is the question everyone should ask Replicor..
what is replicor's next plan? any clue? why is it not published in some reputed journal?
So you are saying they pose bogus data? I tend to believe their results.
Believe me HBV is curable with what is available today that they wont release today.
i m not saying that its bogus data. i am only suggesting why don't they publish in good journals to get scince community attention and publish it in media to get public, government, investors attention.
The whole abstract is posted here on forums as study summary so this is all legit. I think djxpress posted it.
stef .. can you tell what is the recommended dosage of zadaxin?
i m not expert on its use, anyway these italian health pages describe its use as vaccine booster and doses according to kg of weight, if you use chrome translation to english should not be bad
Chronic Hepatitis B
The recommend-ed dose of ZADAXIN (thymalfasin) for chronic hepatitis B when used as a monotherapy or in combination with interferon (at the labeled dose and schedule for interferon) is 1.6 mg (900 µg/m2) administered subcutaneously twice a week for 6 to 12 months. Patients weighing less than 40 kg should receive a ZADAXIN (thymalfasin) dose of 40 µg/kg.
People. We need to start an online action on all HBV forums in every country.
Replicor is the cure. their treatment can give us a new life. A real life. We need to atop talking about TDF EtV and all that. This is what people should focus on.
As for FDA dont worry about them. Getting treatment outside the US is no problem.
Here is the list of Replicor associated research institutions. Lets start contacting them also.
people if we want to have a chance to live we need to get this medicine. It is available and it works.
replicor replicor and replicor , it is the the solution those people are putting in their locker for god sake who can contact them or the people who were in trial ,please contact them and try to find out some thing usrful for us people.we need this at any cost this community has to pay. USA people please wake up u r the hope of world.
We need a big pharma to buyout the maker of REP 9AC and get it all out in the open market. At least a trial involving a large scale.
So far a lot of promising new drugs for Hep B and let's hope a cure is on the horizon. Let's all pray for the sake of humanity.
The only way I see this going anywhere is to get the media involved.
As for cures yes there are better treatments available and drugs that can be used today.
I am following this drug since 2009 and I think we are very close to the end...!!!
I suggest to release a Face book address under name of
( STEP FOR HBV CURE),
then we can see the amount of followers for this account and can write to Replicor company and.....etc.
Now we need a volunteer to establish this account and release(unfortunately I am not expert in such job)..
thats very good idea MHMD. why not we start a new our own website ,funding can be come from inside us mebers. then further members can register for free. this will help a lot to put our voice and making people aware. So members who are from software or have knowledge of web hosting should take initiative without having a doubt in mind, we all are with you. at least we shoud try as collective power, instead of individual. we can force those greedy pharma to follow their responsibility towards society.