you are right, more and more scientific papers look over the qHBsAg so it seams that this will be a important marker for the future.
Anyway, this is somehow normal, the aim of the tx is HBsAg seroconversion so the quantity is important.
Thanks, now I can see it.
I noticed more and more scientific papers include qHBsAg numbers in their papers.
Cheers.
http://trs.scivee.tv/node/1198
this is the link (I just try a copy paste and it work from my side).
I only point out the other study that say that the qHBsAg and DNA are not correlated, but I'm totally agree with StephenCastlecrag that the qHBsAg representing something and it worth to be study and for now we can say that the qHBsAg can say something about the tx.
hbsag
if that is significalntly decrease even air or normal decrease by time is ok.to me that's really nothing on hbeag neg....a significant deacrease of hbsag is when it reaches 1log or goes down continuatively like 0,5log per year
alinia beats both interferon and etv in this although like both inf and etv there are many non responders and also hbsag goes up and down but never undetactable, at least in our experience of less than 2 years
I cannot follow your link. Please check the address.
In my opinion,
1. Low qHBsAg < 250 IU/mL (as Stef2011 stated) predicts a good chance of clearing HBsAg, meaning your treatment is working well or that you don't need treatment.
2. qHBsAg before and during treatment, can predict whether the treatment is working, that you should continue or switch (especially true for Inteferon).
3. Assay for qHBsAg is cheaper than that for hbvdna - so can qHBsAg replace hbvdna as a diagnostic and/or monitoring assay? In my opinion, no. We need both.
4. At the moment patients in Australia and America cannot ask for qHBsAg, because, I suspect, the interpretation of the result is not precise enough. But qHBsAg is certainly used in scientific and clinical studies by doctors and scientists. It is a valuable tool.
Bottom line, qHBsAg levels have meanings, and scientists are working to understand them.
Hope I got it right.
in this http://trs.scivee.tv/node/1198 they say that modest correlation (HBeAG +) or very week correlation (HBeAG -) between HBV DNA and qHBsAG was foud and also say that qHBsAG is decrees under tx (ETV) (only 3 patients increase qHBsAG under tx)
I agree. It is not an easy paper to read and it has a very misleading title.
when hsag is lower than 1500iu/ml the most have normal/near normal alt and hbvdna 3logs, in particular they have immune control of infection
the contrary has no correlation....hbvdna undetactable is not correlated to low hbsag or immune control and sometimes even alt are not normal, i think this is the reason for not considering hbvdna undetactable
Patients with hbvdna = 0 are excluded from the studies - so what can we say about HBsAg levels when hbvdna is low?