Aa
Should I start treatment or wait for cure for Hep B?
Hi guys,
Since 2011 up until now my HBsAg has been raging from 1000 UI/ml - 2200 UI/ml and my fibromax test was between F2 (0.55 value) in 2014 (lowest value) , and F3 (0.72 value) back in 2011 , now in 2015 I have 0.63 so F3. My ALT and AST in normal value. Been reading a lot and seems like in 2-3 year a 100% cure should be on the way. Never treated the disease before in any way, got it at birth, I am aged 30. So any opinion would be very appreciate since I am new here. Doc says 1 year interferon then entecavir. tnx
Since 2011 up until now my HBsAg has been raging from 1000 UI/ml - 2200 UI/ml and my fibromax test was between F2 (0.55 value) in 2014 (lowest value) , and F3 (0.72 value) back in 2011 , now in 2015 I have 0.63 so F3. My ALT and AST in normal value. Been reading a lot and seems like in 2-3 year a 100% cure should be on the way. Never treated the disease before in any way, got it at birth, I am aged 30. So any opinion would be very appreciate since I am new here. Doc says 1 year interferon then entecavir. tnx
There's no study about 100% cure rate because for now drugs are not so good. But for example there is a study about treating HBe negative patients with some odds:
http://www.aphc.info/wp-content/uploads/2014/09/Pietro_LAMPERTICO1.pdf
http://www.aphc.info/wp-content/uploads/2014/09/Pietro_LAMPERTICO1.pdf
Do any of you guys have a chart or link/ study about the 100% cure rate of Interferon / Intecavir and Viread ? I am interested what are the real chances if I start this now, statistically speaking ofc
Sorte I said 2020, that wasn't baseless.. I keep reading things and know baseless statements can harm. Here is what I read and then speculated.
"That said, to date there are still only two families of drugs to treat chronic hepatitis B, the interferons and the polymerase inhibitors. But this is clearly going to change. Based on some of the investigational agents in the pipeline that we describe in this review, we predict that within five years there will be at least two new drugs approved for management of chronic hepatitis B, and within ten years, there should be functional cures."
http://www.sciencedirect.com/science/article/pii/S016635421500145X#b0590
U never know who has what knowledge. Never underestimate anyone u never know who is behind the picture.
"That said, to date there are still only two families of drugs to treat chronic hepatitis B, the interferons and the polymerase inhibitors. But this is clearly going to change. Based on some of the investigational agents in the pipeline that we describe in this review, we predict that within five years there will be at least two new drugs approved for management of chronic hepatitis B, and within ten years, there should be functional cures."
http://www.sciencedirect.com/science/article/pii/S016635421500145X#b0590
U never know who has what knowledge. Never underestimate anyone u never know who is behind the picture.
you are extremely wrong, people here can get to know each other and there are scientists like few in the world in here
people come on to the forums anonymously and take advice from members. When stef and studyofhope post on this forum they dont give you there credentials but you still listen to their advice. If they dont give you their credentials are they expert opinions. I am in no way doubting their expertise but you contradicted yourself, but who cares Im on ignore mode.... WOW
I'm very optimistic, I see results from Replicor or ARC-520 and it gives a lots of hope. That's why I eat healthy and try not to worry a lot. I never posted any negative comment about developed therapies.
I see you now understand, you finally posted experts opinions not your own speculations and it's great change, that's what I mean. Let's finish that discussion, better for our health :)
I see you now understand, you finally posted experts opinions not your own speculations and it's great change, that's what I mean. Let's finish that discussion, better for our health :)
your such a pessimistic.
Hope for a cure
Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists
‘All-star’ researchers intend to develop breakthrough therapies for the viral liver infection within 3 years
DOYLESTOWN, Pa. (March 2015) – The Baruch S. Blumberg Institute (www.blumberginstitute.org) has recruited a new team of nationally renowned scientists to focus exclusively on research to develop a cure for hepatitis B, a move that nearly triples its research capacity and has created the largest concentration of nonprofit scientists focusing solely on hepatitis B and liver cancer in the United States.
Four principal scientists – Drs. Timothy Block, Jinhong Chang, Ju Tao Guo and Ying-Hsiu Su – and 16 of their staff members and laboratory researchers joined the Baruch S. Blumberg Institute full-time on March 1. Establishing this first-rate scientific team of leading hepatitis B researchers lays the groundwork to support an aggressive plan to develop breakthrough therapies to combat the virus within the next three years.
“By bringing leading researchers in the field together at its headquarters, the Hepatitis B Foundation, through its research arm, the Baruch S. Blumberg Institute, is able to concentrate their joint efforts to finding new treatments and, ultimately, a cure,” said Joel Rosen, Chairman of the Foundation’s board. “In the twelve years that I have been a member of the foundation’s board of directors, I have never been more optimistic that a cure is within reach. It’s an exciting time for everyone involved.”
The researchers will build upon recent discoveries that have accelerated the momentum for developing a cure for hepatitis B and liver cancer. Those breakthroughs include the development of new screening methods to search for effective drugs, new ways to treat hepatitis B using different approaches to shut down the virus, a new blood biomarker that aids in the early detection of liver cancer, and a promising drug that selectively kills liver cancer cells in animal studies.
“This is an incredibly exciting time in hepatitis B research, with the field poised to develop a cure. The Blumberg Institute is fortunate to have attracted Tim Block and his colleagues, positioning the nonprofit institute to maintain its world-class stature in hepatitis research,” said Dr. Tom Shenk, one of the nation’s leading virologists, a professor at Princeton University, and a member of the Foundation’s Board of Directors.
Block co-founded the Hepatitis B Foundation and is the president of the Blumberg Institute. For years, he has donated his time to both nonprofit entities, working full-time as a professor of Microbiology and Immunology at Drexel University College of Medicine, where he was Director of the Drexel Institute for Biotechnology and Virology Research. He has left that post in order to dedicate all of his time and focus to the work of the Blumberg Institute.
“The years that we all have spent working towards a cure for hepatitis B have laid the groundwork for this final phase,” said Block. “We are committing everything we have, every resource at our disposal, to developing the therapies that will improve the lives of the millions of people worldwide who live with the hepatitis B virus every day, as well as the risk of dying prematurely from its most fatal consequence, liver cancer.”
With promising drugs in the research pipeline, the Hepatitis B Foundation and the Blumberg Institute have begun exploring relationships with companies that can take those discoveries from the lab to the clinic, where they can benefit people worldwide.
Welcome BSBI scientists 002
The Baruch S. Blumberg Institute has recruited four world-class scientists and their staff members and researchers to generate breakthrough discoveries for hepatitis B and liver cancer. Left to right: Drs. Ying-Hsiu Su, of Audubon, Pa.; Jinhong Chang, of Chalfont, Pa.; Timothy Block, of Doylestown, Pa., and Ju Tao Guo, of Lansdale, Pa. (March 2015)
“The fact that Dr. Tim Block and other world-class scientists have chosen to join the Blumberg Institute in its drive to find a cure for hepatitis B speaks volumes about the Institute’s cutting-edge science and potential to impact global health,” said Wayne Yetter, former president and CEO of the multinational pharmaceutical company Novartis U.S. and a recent addition to the Hepatitis B Foundation’s Board of Directors.
In addition to the exciting implications for the world of science and medicine, the new jobs created at the Blumberg Institute are a welcome boost to the local and regional economy of Bucks County and southeast Pennsylvania.
“The Blumberg Institute’s recruitment of four world-class scientists and their staff, including Dr. Timothy Block, is great news for this community,” said Bucks County state Sen. Charles McIlhinney, a longtime supporter of the organization. “The Blumberg Institute, which manages and is located at the Pennsylvania Biotechnology Center, has been responsible for breakthrough discoveries coupled with spectacular jobs and company creation, right here in Bucks County. This is the kind of growth we need.”
Hope for a cure
Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists
‘All-star’ researchers intend to develop breakthrough therapies for the viral liver infection within 3 years
DOYLESTOWN, Pa. (March 2015) – The Baruch S. Blumberg Institute (www.blumberginstitute.org) has recruited a new team of nationally renowned scientists to focus exclusively on research to develop a cure for hepatitis B, a move that nearly triples its research capacity and has created the largest concentration of nonprofit scientists focusing solely on hepatitis B and liver cancer in the United States.
Four principal scientists – Drs. Timothy Block, Jinhong Chang, Ju Tao Guo and Ying-Hsiu Su – and 16 of their staff members and laboratory researchers joined the Baruch S. Blumberg Institute full-time on March 1. Establishing this first-rate scientific team of leading hepatitis B researchers lays the groundwork to support an aggressive plan to develop breakthrough therapies to combat the virus within the next three years.
“By bringing leading researchers in the field together at its headquarters, the Hepatitis B Foundation, through its research arm, the Baruch S. Blumberg Institute, is able to concentrate their joint efforts to finding new treatments and, ultimately, a cure,” said Joel Rosen, Chairman of the Foundation’s board. “In the twelve years that I have been a member of the foundation’s board of directors, I have never been more optimistic that a cure is within reach. It’s an exciting time for everyone involved.”
The researchers will build upon recent discoveries that have accelerated the momentum for developing a cure for hepatitis B and liver cancer. Those breakthroughs include the development of new screening methods to search for effective drugs, new ways to treat hepatitis B using different approaches to shut down the virus, a new blood biomarker that aids in the early detection of liver cancer, and a promising drug that selectively kills liver cancer cells in animal studies.
“This is an incredibly exciting time in hepatitis B research, with the field poised to develop a cure. The Blumberg Institute is fortunate to have attracted Tim Block and his colleagues, positioning the nonprofit institute to maintain its world-class stature in hepatitis research,” said Dr. Tom Shenk, one of the nation’s leading virologists, a professor at Princeton University, and a member of the Foundation’s Board of Directors.
Block co-founded the Hepatitis B Foundation and is the president of the Blumberg Institute. For years, he has donated his time to both nonprofit entities, working full-time as a professor of Microbiology and Immunology at Drexel University College of Medicine, where he was Director of the Drexel Institute for Biotechnology and Virology Research. He has left that post in order to dedicate all of his time and focus to the work of the Blumberg Institute.
“The years that we all have spent working towards a cure for hepatitis B have laid the groundwork for this final phase,” said Block. “We are committing everything we have, every resource at our disposal, to developing the therapies that will improve the lives of the millions of people worldwide who live with the hepatitis B virus every day, as well as the risk of dying prematurely from its most fatal consequence, liver cancer.”
With promising drugs in the research pipeline, the Hepatitis B Foundation and the Blumberg Institute have begun exploring relationships with companies that can take those discoveries from the lab to the clinic, where they can benefit people worldwide.
Welcome BSBI scientists 002
The Baruch S. Blumberg Institute has recruited four world-class scientists and their staff members and researchers to generate breakthrough discoveries for hepatitis B and liver cancer. Left to right: Drs. Ying-Hsiu Su, of Audubon, Pa.; Jinhong Chang, of Chalfont, Pa.; Timothy Block, of Doylestown, Pa., and Ju Tao Guo, of Lansdale, Pa. (March 2015)
“The fact that Dr. Tim Block and other world-class scientists have chosen to join the Blumberg Institute in its drive to find a cure for hepatitis B speaks volumes about the Institute’s cutting-edge science and potential to impact global health,” said Wayne Yetter, former president and CEO of the multinational pharmaceutical company Novartis U.S. and a recent addition to the Hepatitis B Foundation’s Board of Directors.
In addition to the exciting implications for the world of science and medicine, the new jobs created at the Blumberg Institute are a welcome boost to the local and regional economy of Bucks County and southeast Pennsylvania.
“The Blumberg Institute’s recruitment of four world-class scientists and their staff, including Dr. Timothy Block, is great news for this community,” said Bucks County state Sen. Charles McIlhinney, a longtime supporter of the organization. “The Blumberg Institute, which manages and is located at the Pennsylvania Biotechnology Center, has been responsible for breakthrough discoveries coupled with spectacular jobs and company creation, right here in Bucks County. This is the kind of growth we need.”
What they say it's true, combo therapy is currently the best option, nothing to add so I say nothing.
I'd love to see a lot of timeframes but from experts like studyforhope, not from random people. When some new user logs in and see speculations like, maybe in 2020 or maybe in 10 years he doesn't know if person typing it is expert and may feel depressed.
I'd love to see a lot of timeframes but from experts like studyforhope, not from random people. When some new user logs in and see speculations like, maybe in 2020 or maybe in 10 years he doesn't know if person typing it is expert and may feel depressed.
by posting comments about research and time frames for cure provides hope for people. If we do not have hope, what do we have? Since you are on PEG and taking suggestions from people that have tried to cure or cured isnt that hope. You take a situation which is dark and gloomy for people and you give them a glimpse of light in a long dark tunnel.
when other members say our best chance is combo therapy for cure you do not say anything against them, but when we state there is chance for cure in the next X amount of years you get upset.
when other members say our best chance is combo therapy for cure you do not say anything against them, but when we state there is chance for cure in the next X amount of years you get upset.
Hello,
@hepbcurepls thank you for the details about each one, I have sent it in a mail and will ask my Doc this Wednesday
About the the "future cure" this new study gives me hope
http://www.wehi.edu.au/news/news/eureka-prize-win-hepatitis-b-cure
Will keep you posted of my decision. As usual I do all my investigations every 6 months.
@hepbcurepls thank you for the details about each one, I have sent it in a mail and will ask my Doc this Wednesday
About the the "future cure" this new study gives me hope
http://www.wehi.edu.au/news/news/eureka-prize-win-hepatitis-b-cure
Will keep you posted of my decision. As usual I do all my investigations every 6 months.
It's great to talk and hear about future drugs, but we really don't know the terms. We already have some good drugs in late trials like replicor, they just need to find a dose and order in combination therapy, when to add nucs/peginf or some immune stimulant, but it takes time.
Sorte I know that I don't know much about the arrival and potentiality of the future drugs but talking or hearing about them gives some contentment. I want to hear something new of them whatever aspect and keep searching infos. I am sorry if someone gets upset by my speculations and request to ignore them if one finds irrelevance, but I seek an excuse that I can't stop talking them coz it gives some hope in the darkness. Speculations satisfy desires.
Guys, could you think twice before you post any comments about the terms of the future hbv cure, it's just my kind petition, do whatever you like. But notice that with speculations like this you don't help anyone and no one of you is a specialist.
Damage to the liver is done by immune system not HBV alone. When ALT raises it shows inflamed liver. ALT rises can be from different things so check if you have fatty liver and if no fatty liver ALT rise over 30 iu is considered damage by hep b according to guidelines. The 2 most common ways to check if you have damage in liver is by fibroscan and biopsy. Hardly anyone does biopsy anymore because it is to invasive plus you can only do 1 biopsy every 3 years +. Most of us do a test called fibroscan which measures stiffness of your liver.
HBSAG quantitative test how much antigen virus is in your blood at the time. When this becomes 0 you have a chance of developing antibodies. The higher it is the stronger infection is in your liver. This in conjunction with HBV dna gives you a understanding of your virus in your liver
CBC is a complete blood count test. WBC is a test for white blood cells. It is said when you have cirrhosis of the liver your white blood cells will be low and your platelets in your blood will be low. There is a poor mans biopsy that measures the AST , WBC and platelets to determine if you have liver damage. It is not 100% reliable and fibroscan is needed to truly measure liver damage. Serum creatinine is a test to measure creatinine in the blood because and assess kidney damage. If you have no kidney damage and need to start treatment tenofovir (TDF ) is recommended over entecavir (ETF) because of tumors created in mouse models and mitochondrial toxicity of cells. Long term TDF is more safe at this point in time. As Stephen pointed out there are many potential treatments in the near future, but cure will be close to 10 + years away. The best thing you can do as of now like the rest of us is to preserve liver function and wait for a cure.
The liver is really strong and partying will not damage the liver as much as you think. I am 37 and I started smoking cigs at age 13 quit at 32, was drinking at age 21 up to 32, plus occasional drug use from marijuana to mdma and my liver is still fine, plus I am overweight with fatty liver. Do not worry about the pass and think of the future and how to improve your liver now. Start exercising eating healthy and takes MEDS if you have to.
HBSAG quantitative test how much antigen virus is in your blood at the time. When this becomes 0 you have a chance of developing antibodies. The higher it is the stronger infection is in your liver. This in conjunction with HBV dna gives you a understanding of your virus in your liver
CBC is a complete blood count test. WBC is a test for white blood cells. It is said when you have cirrhosis of the liver your white blood cells will be low and your platelets in your blood will be low. There is a poor mans biopsy that measures the AST , WBC and platelets to determine if you have liver damage. It is not 100% reliable and fibroscan is needed to truly measure liver damage. Serum creatinine is a test to measure creatinine in the blood because and assess kidney damage. If you have no kidney damage and need to start treatment tenofovir (TDF ) is recommended over entecavir (ETF) because of tumors created in mouse models and mitochondrial toxicity of cells. Long term TDF is more safe at this point in time. As Stephen pointed out there are many potential treatments in the near future, but cure will be close to 10 + years away. The best thing you can do as of now like the rest of us is to preserve liver function and wait for a cure.
The liver is really strong and partying will not damage the liver as much as you think. I am 37 and I started smoking cigs at age 13 quit at 32, was drinking at age 21 up to 32, plus occasional drug use from marijuana to mdma and my liver is still fine, plus I am overweight with fatty liver. Do not worry about the pass and think of the future and how to improve your liver now. Start exercising eating healthy and takes MEDS if you have to.
Stephen by saying 2yrs u have shed a bit of happiness though it may be later but still it gives a hope for new sun rays of cure.
It will not come before 2020. No updates are available for myrcludex and rep9ac still says will take time like it said in 2010. I am trying to get some trial place of any of these drugs but have not set out yet. No trials in india. Wish it was India for rep9 instead of Bangladesh.
It will not come before 2020. No updates are available for myrcludex and rep9ac still says will take time like it said in 2010. I am trying to get some trial place of any of these drugs but have not set out yet. No trials in india. Wish it was India for rep9 instead of Bangladesh.
I just want to say it is unrealistic to expect a cure for HBV within the next two years. There are several drugs being investigated, but they are in the very early stages. None of them seems to be a magic bullet that can cure Hepatitis B with a short course of treatment. The new drugs would most likely be used in combination with existing drugs, such as Tenofovir, Entecavir. and Pegylated Interferon.
So it would be a better strategy to have treatment to stop disease progression, make sure the liver remains in a good state, and wait for the new cure treatment that will certainly happen in the not too distant future.
So it would be a better strategy to have treatment to stop disease progression, make sure the liver remains in a good state, and wait for the new cure treatment that will certainly happen in the not too distant future.
Hi,
What are these:
hbsag quant?
cbc , wbc, rbc, platelets etc (including serum creatinine)
hbv genotype and mutations ? I am new here and do not know the short terms.
My mom also has HBV but NOT HCC. I believe I got it from her. In the previous message there has been a mistake my ALT is 40.6 [10-50] and AST 20.4 [10-50]
I tend to believe I damaged my liver really hard, and simply did not care, around my highschool and college years when I was partying a lot. Anyway, I am still not confident if I should start now or wait. If we are to take a look back, from 2011 up until now the virus did no do any damage , it just sits there. But since 2011 until now I stopped drinking alcohol and maintained a more healthier life. Regards
What are these:
hbsag quant?
cbc , wbc, rbc, platelets etc (including serum creatinine)
hbv genotype and mutations ? I am new here and do not know the short terms.
My mom also has HBV but NOT HCC. I believe I got it from her. In the previous message there has been a mistake my ALT is 40.6 [10-50] and AST 20.4 [10-50]
I tend to believe I damaged my liver really hard, and simply did not care, around my highschool and college years when I was partying a lot. Anyway, I am still not confident if I should start now or wait. If we are to take a look back, from 2011 up until now the virus did no do any damage , it just sits there. But since 2011 until now I stopped drinking alcohol and maintained a more healthier life. Regards
Ya rite Elijah , everyone is in hope for a cure and soothen their heart by talking or reading even a bit about it. But the ground reality is its atleast 5 years away from now yet uncertain.
I think most people on here want a complete cure and not have to live with this for the rest of their lives. I've been on treatment for over a year and it's brutal. Nobody wants to take a pill or jab a needle for life.
you should do a full cbc, ultrasound, fibroscan and make a decision from there. starting treatment also harms the body. the whole point of treatment is to lower viral load to reduce risk of cirrhosis and hcc. you should do these test as they are very important
1. hbsag quant
2. hbv dna
3. abdominal ultrasound
4. fibroscan not fibromax
5. cbc , ast , alt, wbc, rbc, platelets etc (including serum creatinine)
6. hbv genotype and mutations
do you have any family members with hcc 1st or 2nd degree relative? What is your age? These are all factors that warrant treatment or not? There are members here in the community with fluctuating hbv dna from 200 - 18000 that are not on treatment. make sure you check all the test above and make a decision from there. do not be in a hurry to start treatment as HBV only damages liver from immune response. i notice your alt at 55 is not considered normal range for hbv.
1. hbsag quant
2. hbv dna
3. abdominal ultrasound
4. fibroscan not fibromax
5. cbc , ast , alt, wbc, rbc, platelets etc (including serum creatinine)
6. hbv genotype and mutations
do you have any family members with hcc 1st or 2nd degree relative? What is your age? These are all factors that warrant treatment or not? There are members here in the community with fluctuating hbv dna from 200 - 18000 that are not on treatment. make sure you check all the test above and make a decision from there. do not be in a hurry to start treatment as HBV only damages liver from immune response. i notice your alt at 55 is not considered normal range for hbv.
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