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Side effects of therapy

Hi there,

I would like to discuss my Viread "side effects" with you. But first some relevant data.
Got diagnosed with Chronic Hep B in March 2011:

- Hbeag Negative
- Genotype D
- Grading 0-1
- Male

Started Viread (Tenofovir) in April:

- HBV DNA in April: 29.000
- HBV DNA in May: 45
- HBV DNA in August: Undetectable
- Hbsag in August: 30.000 (First time it got measured.)

So far so good, but here comes the "strange" data:

- ALT in April and before: Between 65 and 73
- ALT in  May after I started Viread: 93
- ALT in August: 93

Besides I have some "side effects" since I have been taking Viread that one could sum up as the typical symptoms of acute hepatitis b OR the side effects under Interferon:

- Pain over the location of the liver (on the right side of the abdomen, under the lower rib cage). I never experienced that before taking Viread
- Flu like symptoms: Muscle aches; Headache, Temperature, Tiredness. They come and go. Again I did not experience that before.

My doctor says this COULD be some immune reaction but wants to wait for the next results in November. Because she was also a bit surprised by the rise of my ALT since she figured it should have rather dropped considering the decrease of my HBV DNA.

Any ideas out there? Anyone who experienced something like that in therapy? Would be glad to hear your thoughts and opinions. And thanks for this community here!

Keep it up!

44 Responses
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Avatar universal
Dear All. Want to share my latest results with you all.

June 2012
Viral DNA=2.06 copies per ml (Below quantifiable range)
Liver function: Very Good
SGPT (ALT): 9
SGOT (AST): 22.
HBeAG: Negative
HBeAB: Positive

Before i started taking Viread (September 2011)
SGPT (ALT): 9 and SGOT (AST): 15.
Still on Viread + Alinia since Nov 2011.

When i was first diagnosed HBSAG + (March 2011)
HBsAG : Positive
Viral DNA=00/ Undetectable
Liver function: Very Good
Hep B Core Antibody: Positive
Anti HBe (igM): Negative
Anti HBe (igG)  (H): Positive.
HBeAG: Negative
HBeAB: Positive

Not still been able to find a place to do HBSAG quantity test in Nigeria. Going to the US next week on a course for 1 week. Really wish I cld locate a place to have it done.
What do u think abt my results so far? Still on Viread + Alinia. Asked my doctor to put me on Peg Interferon. But he said my immune system is working and would clear naturally oveer time.
Helpful - 0
Avatar universal
Any update on your HBSAG and HBSAB count?
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Avatar universal
Thanks, will try to work on this too!
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Avatar universal
hi stef.. what vits and antiox are reccomended for this purpose???
Helpful - 0
Avatar universal

that's the reason of abnormal alt probbly, see the post:

update on my fatty liver

some vitamins and antioxidants can get rid of it
Helpful - 0
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