Story so far

[aberdeen577]

Hello Everyone,
Right now my stats are :
E antigen negarive
S antigen positive
qHBsAg 16.40 IU/ML
anti HBs <10.00 IU/ML
ALT 29
AST 24
GGT 21
ALP 37
Calcium 2.27 mmol/L
adjusted calcium 2.27 mmol/L

I am currently taking
TDF 1x245mg tablet/day (since September 2011)
Simvastatin 1x20mg tablet per day
Vitamin D3 1x5000IU tablet per day
Blueberry extract 3x60mg tablets per day
Selenium tablet (1) per day

I met with my consultant today and I am so depressed now and disappointed. He will not put me on peginf.because:
-my age
-I have severe fibrosis saying inf can cause liver damage and decompensation
-caucasion
-he has no clinical evidence that it will work with someone so low as 16IU. Says surface antigen needs to be around 500IU/ML for it to work
-it is dangerous to take
-my ALT and AST are too normal; would prefer them elevated
I feel very low now and cannot understand why he cant at least try it for a few months at least.

My question to my learned friends is what can I do now?  I would like to self medicate other oral drugs as a first line to seroconversion before inf. Stef, can you suggest a drug regime that I could look at taking? Inf looks to be a little way off for me right now. I am in N Ireland and I do not have any choice of where to go next.
Thank you.

[stef2011]

Try naturzl ways to lower bp first, im not expert on it but it should be due to inflammed and hardened veins but who knows.gcmaf should not be the cause of it at all nor vit d

changes of nagalase are slow, from 6 to 12 months to make it normal when low, years when high like mine that was around 7
lowering also depends on the source of it and immune system able to suppress that

[joc2011]

Your increase might be the result of all the immune reactivation and clearance. I had that too, had very high BP in the past but mines down to normal again. Liquid COQ-10 and Hybiscus tea definitely did the magic. You should try this.

[aberdeen577]

Just got nagalase test result. It has gone down from 2.2 to 1.8 from beginning november to end january.Unfortunately I vouldnt change last order to stab vit D, goliec had been sent but I will go back to stab vit D next time. i guess I will have to continue for longer than I thought. Downward movement has been relatively small.

Also, i had been with my GP to get prescription for more simvastatin and on checking my bp he found it to be 174 over 101. Now my bp was always pretty normal up to this so I am wondering would the gcmaf be causing this. I am not on any meds yet for hypertension, is this classed as high?

[aberdeen577]

Thank you, I am praying that it will come to zero and then the anti body will begin to go up.

[aberdeen577]

Agreed Stef. However my inf 6 month treatment was in 2000. They stopped it because they told me it was not going got work. When I think back about this how could they say that? They never did a surface antigen test so how could they know if it was working or not. In any case I did not start TDF until 11 years later. I am really hoping that my nagalase will be well reduced now and, if it is, then we can say that my immune response must be stronger.

[stef2011]

I did have 6 months of alpha interferon ( 3 injections per week) back in 2000 and this may have helped lower sag in the first place?

probable, most of hbsag decrease is in the first 6 months if any response is achieved and the lowering goes on after pegintf stop especially if you started tdf after that